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dc.creatorFontanellas-Romá, A. (Antonio)-
dc.creatorDongiovanni, P. (Paola)-
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)-
dc.creatorBarajas, M. (Miguel)-
dc.creatorDi Pierro, E. (Elena)-
dc.creatorÁvila-Zaragozá, M. (Matías)-
dc.creatorMoreno-Aliaga, M. J. (María Jesús)-
dc.creatorPeñuelas-Sanchez, I. (Ivan)-
dc.creatorCollantes, M. (María)-
dc.creatorSampedro, A. (Ana)-
dc.creatorSolares, I. (Isabel)-
dc.creatorUrtasun, R. (Raquel)-
dc.creatorRiezu-Boj, J.I. (José Ignacio)-
dc.creatorCórdoba-Quiñones, K. M. (Karol Marcela)-
dc.creatorJericó-Asenjo, D. (Daniel)-
dc.creatorLongo, M. (Miriam)-
dc.date.accessioned2024-01-31T12:41:32Z-
dc.date.available2024-01-31T12:41:32Z-
dc.date.issued2023-
dc.identifier.citationFontanellas-Romá, A. (Antonio); Dongiovanni, P. (Paola); Milagro-Yoldi, F.I. (Fermín Ignacio); et al. "Nutritional Interventions with Bacillus coagulans Improved Glucose Metabolism and Hyperinsulinemia in Mice with Acute Intermittent Porphyria". International Journal of Molecular Sciences. 24 (15), 2023, 1 - 19es_ES
dc.identifier.urihttps://hdl.handle.net/10171/68675-
dc.description.abstractAcute intermittent porphyria (AIP) is a metabolic disorder caused by mutations in the porphobilinogen deaminase (PBGD) gene, encoding the third enzyme of the heme synthesis pathway. Although AIP is characterized by low clinical penetrance (~1% of PBGD mutation carriers), patients with clinically stable disease report chronic symptoms and frequently show insulin resistance. This study aimed to evaluate the beneficial impact of nutritional interventions on correct carbohydrate dysfunctions in a mouse model of AIP that reproduces insulin resistance and altered glucose metabolism. The addition of spores of Bacillus coagulans in drinking water for 12 weeks modified the gut microbiome composition in AIP mice, ameliorated glucose tolerance and hyperinsulinemia, and stimulated fat disposal in adipose tissue. Lipid breakdown may be mediated by muscles burning energy and heat dissipation by brown adipose tissue, resulting in a loss of fatty tissue and improved lean/fat tissue ratio. Probiotic supplementation also improved muscle glucose uptake, as measured using Positron Emission Tomography (PET) analysis. In conclusion, these data provide a proof of concept that probiotics, as a dietary intervention in AIP, induce relevant changes in intestinal bacteria composition and improve glucose uptake and muscular energy utilization. Probiotics may offer a safe, efficient, and cost-effective option to manage people with insulin resistance associated with AIP.es_ES
dc.description.sponsorshipThis research was supported in part by grants from the Spanish Institute of Health Carlos III (FIS) cofunded by the European Union (ERDF/ESF, “A way to make Europe”/“Investing in your future” (grant number PI21/00546) and the Spanish Fundación Mutua Madrileña de Investigación Médica. The financial sponsors had no role in the analysis or the development of conclusions. The investigators are solely responsible for the content and the decision to submit the manuscript for publication.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectGlucose homeostasises_ES
dc.subjectGut microbiomees_ES
dc.subjectHepatic porphyriaes_ES
dc.subjectInsulin resistancees_ES
dc.subjectMetabolic diseasees_ES
dc.subjectNutritional interventiones_ES
dc.subjectProbioticses_ES
dc.titleNutritional Interventions with Bacillus coagulans Improved Glucose Metabolism and Hyperinsulinemia in Mice with Acute Intermittent Porphyriaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/24/15/11938es_ES
dc.editorial.note© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY)es_ES
dadun.citation.endingPage19es_ES
dadun.citation.number15es_ES
dadun.citation.publicationNameInternational Journal of Molecular Scienceses_ES
dadun.citation.startingPage1es_ES
dadun.citation.volume24es_ES

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