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dc.creatorAlegre, F. (Félix)-
dc.creatorLandecho, M.F. (Manuel F.)-
dc.creatorHuerta, A. (Ana)-
dc.creatorFernandez-Ros, N. (Nerea)-
dc.creatorMartinez-Urbistondo, D. (Diego)-
dc.creatorGarcia, N. (Nicolás)-
dc.creatorLucena-Ramírez, J.F. (Juan Felipe)-
dc.identifier.citationAlegre, F. (Félix); Landecho, M.F. (Manuel F.); Huerta, A. (Ana); et al. "Design and Performance of a New Severity Score for Intermediate Care". PLoS ONE. 10 (6), 2015, e0130989es
dc.description.abstractBackground Application of illness-severity scores in Intermediate Care Units (ImCU) shows conflicting results. The aim of the study is to design a severity-of-illness score for patients admitted to an ImCU. Methods We performed a retrospective observational study in a single academic medical centre in Pamplona, Spain. Demographics, past medical history, reasons for admission, physiologi- cal parameters at admission and during the first 24 hours of ImCU stay, laboratory variables and survival to hospital discharge were recorded. Logistic regression analysis was per- formed to identify variables for mortality prediction. Results A total of 743 patients were included. The final multivariable model (derivation cohort = 554 patients) contained only 9 variables obtained at admission to the ImCU: previous length of stay 7 days (6 points), health-care related infection (11), metastatic cancer (9), immunosup- pressive therapy (6), Glasgow comma scale 12 (10), need of non-invasive ventilation (14), platelets 50000/mcL (9), urea 0.6 g/L (10) and bilirubin 4 mg/dL (9). The ImCU severity score (ImCUSS) is generated by summing the individual point values, and the formula for determining the expected in-hospital mortality risk is: eImCUSS points*0.099 – 4,111 / (1 + eImCUSS points*0.099 – 4,111). The model showed adequate calibration and discrimination. Performance of ImCUSS (validation cohort = 189 patients) was comparable to that of SAPS II and 3. Hos- mer-Lemeshow goodness-of-fit C test was χ2 8.078 (p=0.326) and the area under receiver operating curve 0.802. Conclusions ImCUSS, specially designed for intermediate care, is based on easy to obtain variables at admission to ImCU. Additionally, it shows a notable performance in terms of calibration and mortality discrimination.es_ES
dc.publisherSan Francisco CA: Public Library of Sciencees_ES
dc.subjectMaterias Investigacion::Ciencias de la Salud::Especialidades médicases_ES
dc.subjectIntermediate carees_ES
dc.subjectSeverity-of-illness scorees_ES
dc.titleDesign and Performance of a New Severity Score for Intermediate Carees_ES
dc.description.noteThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es_ES
dadun.citation.publicationNamePLoS ONEes_ES

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