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dc.creatorGoikoetxea-Miranda, E. (Estibalitz)-
dc.creatorRivas-Nieto, A. (Alejandro)-
dc.creatorMurgia-Esteve, X.(Xabier)-
dc.creatorAntón-Remírez, R. (Raúl)-
dc.date.accessioned2024-02-05T13:04:10Z-
dc.date.available2024-02-05T13:04:10Z-
dc.date.issued2017-03-
dc.identifier.citationGoikoetxea, E., Rivas, A., Murgia, X., & Antón, R. (2017). Mathematical modeling and numerical simulation of surfactant delivery within a physical model of the neonatal trachea for different aerosol characteristics. Aerosol Science and Technology, 51(2), 168-177.es_ES
dc.identifier.issn0278-6826-
dc.identifier.urihttps://hdl.handle.net/10171/68790-
dc.description.abstractSurfactant aerosol delivery in conjunction with a noninvasive respiratory support holds the potential to treat neonatal respiratory distress syndrome in a safe manner. The objective of the present study was to gain knowledge in order to optimize the geometry of an intracorporeal inhalation catheter and improve surfactant aerosol delivery effectiveness in neonates. Initially, a mathematical model capable of predicting the aerosol flow generated by this inhalation catheter within a physical model of the neonatal trachea was implemented and validated. Subsequently, a numerical study was performed to analyze the effect of the aerosol liquid droplet size and mass flow rate on surfactant delivery and on the required aerosolization time period. Experimental validation of the mathematical model showed a close prediction of the air axial velocity at the distal end of the physical model, with an absolute error between 0.01 and 0.15 m/s. Furthermore, an admissible absolute error between 0.2 and 2 mm was attained in the prediction of the aerosol mean aerodynamic diameter and mass median aerodynamic diameter in this region. The numerical study highlighted the beneficial effects of generating an intracorporeal aerosol with a mass median aerodynamic diameter higher than 4 mm and a surfactant mass flow rate above 8.93 mg/s in order to obtain effective surfactant delivery in neonates with minimal airway manipulation.es_ES
dc.description.sponsorshipThe authors would like to acknowledge the support of the Cátedra Fundación Antonio Aranzábal-Universidad de Navarra.es_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francises_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectRespiratory-distsress-syndrome.es_ES
dc.subjectIn-silico models.es_ES
dc.subjectPreterm infants.es_ES
dc.subjectOpen label.es_ES
dc.subjectDeposition.es_ES
dc.subjectVentilation.es_ES
dc.subjectInhalation.es_ES
dc.subjectTherapy.es_ES
dc.titleMathematical modeling and numerical simulation of surfactant delivery within a physical model of the neonatal trachea for different aerosol characteristicses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.editorial.noteCC BYes_ES
dc.identifier.doi10.1080/02786826.2016.1255714-

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