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dc.creatorSotos-Prieto, M. (Mercedes)-
dc.creatorRuiz-Canela, M. (Miguel)-
dc.creatorSong, Y. (Yiqing)-
dc.creatorChristoph, C. (Costas)-
dc.creatorMofatt, S. (Steven)-
dc.creatorRodríguez-Artalejo, F. (Fernando)-
dc.creatorKales, S.N. (Stefanos N.)-
dc.date.accessioned2024-02-06T10:11:41Z-
dc.date.available2024-02-06T10:11:41Z-
dc.date.issued2020-
dc.identifier.citationSotos-Prieto, M. (Mercedes); Ruiz-Canela, M. (Miguel); Song, Y. (Yiqing); et al. "The effects of a mediterranean diet intervention on targeted plasma metabolic biomarkers among US firefighters: A pilot cluster-randomized trial". Nutrients. 12 (12), 2020, 3610es_ES
dc.identifier.issn2072-6643-
dc.identifier.urihttps://hdl.handle.net/10171/68817-
dc.description.abstractMetabolomics is improving the understanding of the mechanisms of the health effects of diet. Previous research has identified several metabolites associated with the Mediterranean Diet (MedDiet), but knowledge about longitudinal changes in metabolic biomarkers after a MedDiet intervention is scarce. A subsample of 48 firefighters from a cluster-randomized trial at Indianapolis fire stations was randomly selected for the metabolomics study at 12 months of follow up (time point 1), where Group 1 (n = 24) continued for another 6 months in a self-sustained MedDiet intervention, and Group 2 (n = 24), the control group at that time, started with an active MedDiet intervention for 6 months (time point 2). A total of 225 metabolites were assessed at the two time points by using a targeted NMR platform. The MedDiet score improved slightly but changes were non-significant (intervention: 24.2 vs. 26.0 points and control group: 26.1 vs. 26.5 points). The MedDiet intervention led to favorable changes in biomarkers related to lipid metabolism, including lower LDL-C, ApoB/ApoA1 ratio, remnant cholesterol, M-VLDL-CE; and higher HDL-C, and better lipoprotein composition. This MedDiet intervention induces only modest changes in adherence to the MedDiet and consequently in metabolic biomarkers. Further research should confirm these results based on larger study samples in workplace interventions with powerful study designs.es_ES
dc.description.sponsorshipThis research was funded by EMW-2014-FP-00612, US Department of Homeland Security, a Ohio University OURC grant and a CHSP Research Innovation grant, and the 2018 Southeast Center for Integrated Metabolomics Pilot & Feasibility Project. M.S.-P. holds a Ramón y Cajal contract (RYC-2018-025069-I) from the Ministry of Science, Innovation and Universities and FEDER/FSE and FIS grant PI20/00896. The funding agencies had no role in study design, data collection and analysis, interpretation of results, manuscript preparation or in the decision to submit this manuscript for publicationes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00896/ES/EL “HEALTHY HEART SCORE” ESPAÑOL: VALIDACION, DESARROLLO Y TRANSFERENCIA A UN ENTORNO LABORAL DE UN MODELO DE PREDICCION BASADO EN ESTILOS DE VIDA PARA LA PREVENCION PRIMORDIAL DE ENFERMEDADES CARDIOVASCULARESes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectMediterranean Dietes_ES
dc.subjectMetaboliteses_ES
dc.subjectClinical triales_ES
dc.subjectLipoprotein compositiones_ES
dc.subjectBiomarkerses_ES
dc.titleThe effects of a mediterranean diet intervention on targeted plasma metabolic biomarkers among US firefighters: A pilot cluster-randomized triales_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.identifier.doi10.3390/nu12123610-
dadun.citation.number12es_ES
dadun.citation.publicationNameNutrientses_ES
dadun.citation.startingPage3610es_ES
dadun.citation.volume12es_ES
dc.identifier.pmid33255353-

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