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dc.creatorMarlin, E. (Elías)-
dc.creatorViu-Idocin, C. (Cristina)-
dc.creatorArrasate, M. (Montserrat)-
dc.creatorAragón, T. (Tomás)-
dc.identifier.citationMarlin, E. (Elías); Viu-Idocin, C. (Cristina); Arrasate, M. (Montserrat); et al. "The role and therapeutic potential of the integrated stress response in amyotrophic lateral sclerosis". Molecular sciences. 23 (14), 2022, 7823es
dc.description.abstractIn amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical and spinal cord motor neurons triggers the activation of the integrated stress response (ISR), an intracellular signaling pathway that remodels translation and promotes a gene expression program aimed at coping with stress. Beyond its neuroprotective role, under regimes of chronic or excessive stress, ISR can also promote cell/neuronal death. Given the two-edged sword nature of ISR, many experimental attempts have tried to establish the therapeutic potential of ISR enhancement or inhibition in ALS. This review discusses the complex interplay between ISR and disease progression in different models of ALS, as well as the opportunities and limitations of ISR modulation in the hard quest to find an effective therapy for ALS.es_ES
dc.description.sponsorshipThis research was funded by MCIN/AEI/10.13039/501100011033, grant number PID2020- 120497RB-I00 and pre-doctoral fellowships (E.M.) AC (CIMA) and Gobierno de Navarra, reference number 0011-0537-2018-000006es_ES
dc.publisherMDPI AGes_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-120497RB-I00/ES/ESTUDIO DEL MECANISMO Y POTENCIAL TERAPEUTICO DEL PROCESAMIENTO Y TRADUCCION DE MARNS EN RESPUESTA ESTRES EN LA ESCLEROSIS LATERAL AMIOTROFICAes_ES
dc.subjectAmyotrophic lateral sclerosises_ES
dc.subjectIntegrated stress responsees_ES
dc.subjectuORFs-containing mRNAses_ES
dc.subjectALS experimental modelses_ES
dc.subjectRNA-binding proteinses_ES
dc.subjectALS clinical trialses_ES
dc.titleThe role and therapeutic potential of the integrated stress response in amyotrophic lateral sclerosises_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/)es_ES
dadun.citation.publicationNameMolecular scienceses_ES

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