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dc.creatorRodríguez-Garijo, N. (Nuria)-
dc.creatorBielsa, I. (I.)-
dc.creatorMascaró-Galy, J.M. (José Manuel)-
dc.creatorQuer, A. (A.)-
dc.creatorIdoate, M.A. (Miguel Ángel)-
dc.creatorParicio, J.J. (J. J.)-
dc.creatorIranzo, P. (Pilar)-
dc.creatorEspaña, A. (Agustín)-
dc.date.accessioned2024-02-06T12:06:49Z-
dc.date.available2024-02-06T12:06:49Z-
dc.date.issued2020-
dc.identifier.citationRodríguez-Garijo, N. (Nuria); Bielsa, I. (I.); Mascaró-Galy, J.M. (José Manuel); et al. "Reactive granulomatous dermatitis as a histological pattern including manifestations of interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis: a study of 52 patients". Journal of the European Academy of Dermatology and Venereology. 35 (4), 2020, 988 - 994es_ES
dc.identifier.issn1468-3083-
dc.identifier.urihttps://hdl.handle.net/10171/68836-
dc.description.abstractBackground: Confusion exists regarding interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic and granulomatous dermatitis (PNGD). Objective: To determine whether IGD and PNGD are two different entities, or whether they must be considered as two subtypes of the same reactive pattern, and thus whether the unification of the nomenclature is necessary. Methods: Observational retrospective multicentre study of patients with IGD and PNGD evaluated between 1999 and 2019 and review of their clinical and histological features. Results: We identified 52 patients (38 women and 14 men). Clinical and histological findings of IGD were observed in 88.4% of cases. The most common cutaneous lesions were plaques/macules (IGD) or annular plaques and papules/nodules (PNGD), located mostly on the limbs and trunk. The rope sign was developed in two patients with IGD that associated autoimmune disorders. Similar associated comorbidities (75%) were found in both entities, mainly autoimmune diseases (53.8%). In IGD, the infiltrate was predominantly lympho-histiocytic. Neutrophilic infiltrates, karyorrhexis and skin lesions with limited clinical course were mainly associated with PNGD biopsies. In biopsies with a limited recurrent course, a predominant lymphocytic inflammatory infiltrate was found. Collagen degeneration was present in 75.9% of cases. The floating sign was observed only in IGD type patients (63%). Overlapping histological findings were found in one fourth of cases, especially between IGD and interstitial granuloma annulare. Interface dermatitis, apparently unrelated to drug intake, was observed in 4 cases of IGD. Conclusion: We support the term reactive granulomatous dermatitis to unify both the clinical and histological findings of IGD and PNGD, and the overlapping between IGD and interstitial granuloma annulare. According to this, a spectrum of histological changes will be found depending on the clinical course of the skin lesions.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.subjectReactive granulomatous dermatitises_ES
dc.subjectPalisaded neutrophilices_ES
dc.subjectInterstitial granulomatous dermatitises_ES
dc.subjectMaterias Investigacion::Ciencias de la Salud::Dermatologíaes_ES
dc.subjectMaterias Investigacion::Ciencias de la Saludes_ES
dc.titleReactive granulomatous dermatitis as a histological pattern including manifestations of interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis: a study of 52 patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1111/jdv.17010-
dadun.citation.endingPage994es_ES
dadun.citation.number4es_ES
dadun.citation.publicationNameJournal of the European Academy of Dermatology and Venereologyes_ES
dadun.citation.startingPage988es_ES
dadun.citation.volume35es_ES
dc.identifier.pmid33098595-

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