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dc.creatorBergón-Sendín, M. (Marta)-
dc.creatorPulido-Pérez, A. (Ana)-
dc.creatorNieto-Benito, L.M. (Lula M.)-
dc.creatorBarchino-Ortiz, L. (Lucía)-
dc.creatorDíez-Sebastián, J. (Jesús)-
dc.creatorSuárez-Fernández, R. (Ricardo)-
dc.date.accessioned2024-02-09T09:51:43Z-
dc.date.available2024-02-09T09:51:43Z-
dc.date.issued2022-
dc.identifier.citationBergón-Sendín, M. (Marta); Pulido-Pérez, A. (Ana); Nieto-Benito, L.M. (Lula M.); et al. "Effectiveness of neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: A prospective cohorts study". Dermatologic Therapy. 35 (2), 2022, e15233es
dc.identifier.issn1396-0296-
dc.identifier.urihttps://hdl.handle.net/10171/68963-
dc.description.abstractIntralesional methotrexate (il-MTX) has been used in cutaneous squamous cell carcinoma (cSCC) achieving important reductions in tumor size. However, there is a lack of controlled studies on this regard. The primary objective was to analyze the effect of il-MTX on tumor size in cSCC. As a secondary objective, we evaluated its impact on the surgical approach. We conducted a prospective cohorts study that included 200 patients with histologically confirmed cSCC. Patients in Group 1 (Cases) received neoadjuvant treatment with il-MTX prior to surgery. Patients in Group 2 (Controls) underwent scheduled surgery without prior neoadjuvant therapy. Clinical measurements of lesions were made at the time of inclusion in the study and before surgery. No intergroup statistical differences were found between the assessed variables. In Group 1, tumor size reduction occurred in 93% of the patients after il-MTX therapy. Tumor surface was reduced by 54%. Complex reconstructions were needed in 15% of these patients. In Group 2, tumor surface increased by 33.1% and complex reconstructions were needed in 40% of patients. Intergroup differences were statistically significant (p < 0.001). Neoadjuvant Il-MTX therapy achieves very important tumor size reduction and significantly simplifies surgical treatment.es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.subjectMaterias Investigacion::Ciencias de la Salud::Dermatologíaes_ES
dc.subjectMethotrexatees_ES
dc.subjectSquamous cell carcinomaes_ES
dc.subjectSurgeryes_ES
dc.subjectTreatmentes_ES
dc.titleEffectiveness of neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: A prospective cohorts studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1111/dth.15233-
dadun.citation.number2es_ES
dadun.citation.publicationNameDermatologic Therapyes_ES
dadun.citation.startingPagee15233es_ES
dadun.citation.volume35es_ES

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