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dc.creatorBertoglio, P. (Pietro)-
dc.creatorAprile, V. (Vittorio)-
dc.creatorVentura, L. (Luigi)-
dc.creatorCattoni, M. A. (Maria Angela)-
dc.creatorNachira, D. (Dania)-
dc.creatorLococo, F. (Filippo)-
dc.creatorRodríguez-Pérez, M.C. (María C.)-
dc.creatorGuerrera, F. (Francesco)-
dc.creatorMinervini, F. (Fabrizio)-
dc.creatorQuerzoli, G. (Giulia)-
dc.creatorBocchialini, G. (Giovanni)-
dc.creatorBacchin, D. (Diana)-
dc.creatorFranzi, F. (Francesca)-
dc.creatorRindi, G. (Guido)-
dc.creatorBellafiore, S. (Salvatore)-
dc.creatorFemia, F. (Federico)-
dc.creatorBogina, G. S. (Giuseppe Salvatore)-
dc.creatorSolli, P. (Piergiorgio)-
dc.creatorKestenholz, P. (Peter)-
dc.creatorRuffini, E. (Enrico)-
dc.creatorPaci, M. (Massimiliano)-
dc.creatorMargaritora, S. (Stefano)-
dc.creatorImperatori, A. S. (Andrea Selenito)-
dc.creatorLucchi, M. (Marco)-
dc.creatorGnetti, L. (Letizia)-
dc.creatorTerzi, A. C. (Alberto Claudio)-
dc.identifier.citationBertoglio, P. (Pietro); Aprile, V. (Vittorio); Ventura, L. (Luigi); et al. "Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis". Lung Cancer. 200, 2022, 649 - 660es_ES
dc.description.abstractObjective The presence of micropapillary and solid adenocarcinoma patterns leads to a worse survival and a significantly higher tendency to recur. This study aims to assess the impact of pT descriptor combined with the presence of high-grade components on long-term outcomes in early-stage lung adenocarcinomas. Methods We retrospectively collected data of consecutive resected pT1-T3N0 lung adenocarcinoma from nine European Thoracic Centers. All patients who underwent a radical resection with lymph-node dissection between 2014 and 2017 were included. Differences in Overall Survival (OS) and Disease-Free Survival (DFS) and possible prognostic factors associated with outcomes were evaluated also after performing a propensity score matching to compare tumors containing non-high-grade and high-grade patterns. Results Among 607 patients, the majority were male and received a lobectomy. At least one high-grade histological pattern was seen in 230 cases (37.9%), of which 169 solid and 75 micropapillary. T1a-b-c without high-grade pattern had a significant better prognosis compared to T1a-b-c with high-grade pattern (p = 0.020), but the latter had similar OS compared to T2a (p = 0.277). Concurrently, T1a-b-c without micropapillary or solid patterns had a significantly better DFS compared to those with high-grade patterns (p = 0.034), and it was similar to T2a (p = 0.839). Multivariable analysis confirms the role of T descriptor according to high-grade pattern both for OS (p = 0.024; HR 1.285 95% CI 1.033–1.599) and DFS (p = 0.003; HR 1.196, 95% CI 1.054–1.344, respectively). These results were confirmed after the propensity score matching analysis. Conclusions pT1 lung adenocarcinomas with a high-grade component have similar prognosis of pT2a tumors.es_ES
dc.subjectLung adenocarcinomaes_ES
dc.subjectTNM staginges_ES
dc.subjectLung canceres_ES
dc.subjectAdenocarcinoma subtypees_ES
dc.titleImpact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysises_ES
dc.editorial.note© The Author(s) 2022es_ES
dadun.citation.publicationNameLung Canceres_ES

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