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dc.creatorGámez-Macías, P.E. (Paola Elizabeth)-
dc.creatorFélix-Soriano, E. (Elisa)-
dc.creatorSamblas-García, M. (Miriam)-
dc.creatorSainz, N. (Neira)-
dc.creatorMoreno-Aliaga, M. J. (María Jesús)-
dc.creatorGonzalez-Muniesa, P. (Pedro)-
dc.identifier.citationGámez-Macías, P.E. (Paola Elizabeth); Félix-Soriano, E. (Elisa); Samblas-García, M. (Miriam); et al. "Intestinal permeability, gut inflammation, and gut immune system response are linked to aging-related changes in gut microbiota composition: A study in female mice". The Journals of Gerontology: Series A. 79 (4), 2024, glae045es_ES
dc.description.abstractAging entails changes at the cellular level that increase the risk of various pathologies. An association between gut microbiota and age-related diseases has also been attributed. This study aims to analyze changes in fecal microbiota composition and their association with genes related to immune response, gut inflammation, and intestinal barrier impairment. Fecal samples of female mice at different ages (2 months, 6 months, 12 months, and 18 months) and gene expression in colon tissue were analyzed. Results showed that the older mice group had a more diverse microbiota than the younger group. Additionally, the abundance of Cyanobacteria, Proteobacteria, Flavobacteriaceae, Bacteroides, Parabacteroides, Prevotellaceae_UCG-001, Akkermansia, and Parabacteroides goldsteinii increased with age. In contrast, there was a notable decline in Clostridiaceae, Lactobacillaceae, Monoglobaceae, Ligilactobacillus, Limosilactobacillus, Mucispirillum, and Bacteroides faecichinchillae. These bacteria imbalances were positively correlated with increased inflammation markers in the colon, including Tnf-α, Ccl2, and Ccl12, and negatively with the expression of tight junction genes (Jam2, Tjp1, and Tjp2), as well as immune response genes (Cd4, Cd72, Tlr7, Tlr12, and Lbp). In conclusion, high levels of diversity did not result in improved health in older mice; however, the imbalance in bacteria abundance that occurs with aging might contribute to immune senescence, inflammation, and leaky gut disease.es_ES
dc.description.sponsorshipThis study was funded by Ministerio de Ciencia e Innovación/ Agencia Estatal de Investigación – European Regional Development Fund (MINECO/FEDER) of the Government of Spain and European Union, respectively (BFU2015-65937-R); by CIBER - Centro de Investigación Biomédica en Red- (CIBEROBN - CB12/03/30002), Instituto de Salud Carlos III; and through the Department of University, Innovation and Digital Transformation, Government of Navarra (PI026 BIOAGEMT).es_ES
dc.publisherOxford University Presses_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Centros de Investigación Biomédica en Red (CIBER)/CB12/03/30002/[ES]/INCORPORACION GRUPOS CIBER FISIOPATOLOGIA DE LA OBESIDAD Y NUTRICION (CIBER OBN)es_ES
dc.subjectGut microbiotaes_ES
dc.subjectImmune responsees_ES
dc.subjectIntestinal barrieres_ES
dc.titleIntestinal permeability, gut inflammation, and gut immune system response are linked to aging-related changes in gut microbiota composition: A study in female micees_ES
dc.description.noteThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licensees_ES
dadun.citation.publicationNameThe Journals of Gerontology: Series Aes_ES

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