Martinez-Gonzalez, M.A. (Miguel Ángel)Toledo, E. (Estefanía)Bes-Rastrollo, M. (Maira)Vitelli-Storelli, F. (Facundo)Vazquez-Ruiz, Z. (Zenaida)Basterra-Gortari, F.J. (Francisco Javier)2023-04-202023-04-202023Vázquez-Ruiz, Z. (Zenaida); Martínez-González, M. (Miguel Ángel); Vitelli-Storelli, F.; et al. "Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort". Antioxidants. 12 (2), 2023, 5072076-3921https://hdl.handle.net/10171/66052The global incidence of type 2 diabetes (T2D) has been steadily increasing in recent decades. The Mediterranean dietary pattern has shown a preventive effect on the risk of T2D. Evaluating the association between bioactive compounds such as phenolic compounds (PC) in a Mediterranean cohort could help to better understand the mechanisms implicated in this protection. We evaluated the association between dietary intake of PC and the risk of T2D in a relatively young cohort of 17,821 Spanish participants initially free of T2D, through the University of Navarra Follow-up Project (Seguimiento Universidad de Navarra or SUN cohort) after 10 years of median follow-up using time-dependent Cox models. Intake of PC was estimated at baseline and repeatedly at 10-year follow-up using a 136-item validated food frequency and the Phenol-Explorer database. The incidence of T2D was identified by a biennial follow-up, and only medically confirmed cases were included. During 224,751 person-years of follow-up, 186 cases of T2D were confirmed. A suboptimal intake of stilbenes was independently associated with a higher risk of T2D in subjects over 50 years (HR: 1.75, 95% CI: 1.06-2.90, p value < 0.05) after adjusting for potential confounders. Our results suggest that a moderate-high intake of stilbenes can decrease the risk of developing T2D in subjects over 50 years in our cohort.eninfo:eu-repo/semantics/openAccessPhenolic compoundsDietDiabetesStilbenesCohortinfo:eu-repo/semantics/article10.3390/antiox1202050736830064