<td class= (Institución)
   (Nuevo usuario)
Ayuda  | Contacto  |  Castellano English  

Dadun > Depósito Académico > Facultad de Ciencias > Departamento de Histología y Anatomía Patológica > DA - Ciencias - HAP - Artículos de revista >

New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification
Autor(es) : Collantes, M. (María)
Prieto-Azcárate, E. (Elena)
Peñuelas, I. (Iván)
Blesa, J. (J.)
Juri, C. (Carlos)
Marti-Climent, J.M. (Josep María)
Quincoces, G. (Gemma)
Arbizu, J. (J.)
Riverol, M. (Mario)
Zubieta, J.L. (José L.)
Rodriguez-Oroz, M.C. (María Cruz)
Luquin, M.R. (María Rosario)
Richter, J.A. (José Ángel)
Obeso, J.A. (José A.)
Palabras clave : New MRIfor
11C-(+)-α-dihydrotetrabenazine templates
Macaca fascicularis neuroimaging
Advantages to improve quantification
Fecha incorporación: 23-abr-2009
Editorial : Elsevier
Versión del editor: http://dx.doi.org/10.1016/j.neuroimage.2009.04.078
ISSN: 1053-8119
Cita: Collantes M, Prieto E, Penuelas I, Blesa J, Juri C, Marti-Climent JM, et al. New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification. Neuroimage 2009 Aug 15;47(2):533-539.
Normalization of neuroimaging studies to a stereotaxic space allows the utilization of standard volumes of interest (VOIs) and voxel-based analysis (SPM). Such spatial normalization of PET and MRI studies requires a high quality template image. The aim of this study was to create new MRI and PET templates of 18F-DOPA and 11C-(+)-α-dihydrotetrabenazine (11C-DTBZ) of the Macaca fascicularis brain, an important animal model of Parkinson's disease. MRI template was constructed as a smoothed average of the scans of 15 healthy animals, previously transformed into the space of one representative MRI. In order to create the PET templates, 18F-DOPA and 11C-DTBZ PET of the same subjects were acquired in a dedicated small animal PET scanner and transformed to the created MRI template space. To validate these templates for PET quantification, parametric values obtained with a standard VOI-map applied after spatial normalization to each template were statistically compared to results computed using individual VOIs drawn for each animal. The high correlation between both procedures validated the utilization of all the templates, improving the reproducibility of PET analysis. To prove the utility of the templates for voxel-based quantification, dopamine striatal depletion in a representative monkey treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was assessed by SPM analysis of 11C-DTBZ PET. A symmetric reduction in striatal 11C-DTBZ uptake was detected in accordance with the induced lesion. In conclusion, templates of M. fascicularis brain have been constructed and validated for reproducible and automated PET quantification. All templates are electronically available via the internet.
Enlace permanente: http://hdl.handle.net/10171/13574
Aparece en las colecciones: DA - CIMA - Servicios de apoyo - Micropet - Artículos de revista
DA - Ciencias - HAP - Artículos de revista
DA - CUN - Medicina nuclear - Artículos de revista

Ficheros en este registro:
Fichero:  Final-Collantes-Prieto review.pdf
Tamaño:  136,9 kB
Formato:  Adobe PDF
 Visualizar / Abrir 
Fichero:  Table review.pdf
Tamaño:  28,81 kB
Formato:  Adobe PDF
 Visualizar / Abrir 
Fichero:  Figuras MRI.pdf
Tamaño:  1,54 MB