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Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Farmacia y Tecnología Farmacéutica > DA - Farmacia - Tecnología Farmacéutica - Artículos de revista >

In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma.
Autor(es) : Mendoza, A. (Adela)
Preat, V. (Veronique)
Mollinedo, F. (Faustino)
Blanco-Prieto, M.J. (María José)
Palabras clave : Edelfosine
Glioma
Lipid nanoparticles
Fecha incorporación: 2011
Editorial : Elsevier
Versión del editor: http://dx.doi.org/10.1016/j.jconrel.2011.07.030
ISSN: 0168-3659
Cita: Estella-Hermoso de Mendoza A, Preat V, Mollinedo F, Blanco-Prieto MJ. In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma. J Control Release 2011 Jul 28.
Resumen
Edelfosine is the prototype molecule of a family of anticancer drugs collectively known as synthetic alkyl-lysophospholipids. This drug holds promise as a selective antitumor agent, and a number of preclinical assays are in progress. In this study, we observe the accumulation of edelfosine in brain tissue after its oral administration in Compritol® and Precirol® lipid nanoparticles (LN). The high accumulation of edelfosine in brain was due to the inhibition of P-glycoprotein by Tween® 80, as verified using a P-glycoprotein drug interaction assay. Moreover, these LN were tested in vitro against the C6 glioma cell line, which was later employed to establish an in vivo xenograft mouse model of glioma. In vitro studies revealed that edelfosine-loaded LN induced an antiproliferative effect in C6 glioma cell line. In addition, in vivo oral administration of drug-loaded LN in NMRI nude mice bearing a C6 glioma xenograft tumor induced a highly significant reduction in tumor growth (p<0.01) fourteen days after the beginning of the treatment. Our results showed that Tween® 80 coated Compritol® and Precirol® LN can effectively inhibit the growth of C6 glioma cells in vitro and suggest that edelfosine-loaded LN represent an attractive option for the enhancement of antitumor activity on brain tumors in vivo.
Enlace permanente: http://hdl.handle.net/10171/19459
Aparece en las colecciones: DA - Farmacia - Tecnología Farmacéutica - Artículos de revista

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