Activation of human T helper 1 and DNAase expression in CD4+ T cells induced by short immunomodulating peptides.
Palabras clave : 
CD4-Positive T-Lymphocytes/drug effects
Deoxyribonucleases/biosynthesis
Peptides/pharmacology
Th1 Cells/drug effects
Adjuvants, Immunologic
Fecha incorporación: 
1994
Editorial : 
Elsevier
ISSN: 
0006-291X
Cita: 
Lopez-Moratalla N, Migliacio M, Lopez-Zabalza MJ, Perez-Mediavilla A, Santiago E. Activation of human T helper 1 and DNAase expression in CD4+ T cells induced by short immunomodulating peptides. Biochem Biophys Res Commun,1994 Dec 30;205(3):2008-2012.
Resumen
Activation of human T helper 1 cells took place when lymphomononuclear cells from healthy donors were incubated in the presence of short synthetic peptides encompassing sequences present in extracellular matrix proteins. Active peptides conformed to a common structural pattern ("2-6-11 motif") [N.López-Moratalla et al., Biochem. Biophys. Acta (1994) 1221, 153-158] conferring immunomodulating properties. The release of IL-2 and IFN gamma, as well as LAK and NK-dependent cytotoxicity induced by these peptides, could be blocked by anti-HLA-DR antibody. Activated CD4+ cells isolated from the mixed incubated population contained secretion granules with DNAase activity. These results suggest that these immunomodulating peptides presented by HLA-II play a key role in the differentiation of CD4+ T cells towards a Th1 functional phenotype.

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Fichero: 
BBRC 205.pdf
Descripción: 
Tamaño: 
270,9 kB
Formato: 
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