t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia
Palabras clave : 
Chromosomes, Human, Pair 10/genetics
Chromosomes, Human, Pair 16/genetics
Leukemia, Monocytic, Acute/genetics
Nuclear Proteins/genetics
Oncogene Proteins, Fusion/genetics
Saccharomyces cerevisiae Proteins/genetics
Trans-Activators/genetics
Fecha de publicación: 
2003
Editorial : 
Wiley-Blackwell
ISSN: 
1098-2264
Cita: 
Vizmanos JL, Larrayoz MJ, Lahortiga I, Floristan F, Alvarez C, Odero MD, et al. t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia. Genes Chromosomes Cancer 2003 Apr;36(4):402-405.
Resumen
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML.

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Fichero: 
2003 MORF-CREBBP.pdf
Descripción: 
Tamaño: 
152,63 kB
Formato: 
Adobe PDF


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