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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Genética > DA - CIMA - Oncología - Genética - Artículos de revista >

t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia
Authors: Vizmanos, J.L. (José Luis)
Larrayoz, M.J. (María J.)
Lahortiga, I. (Idoya)
Floristan, F. (Filomena)
Alvarez, C. (Carmen)
Odero, M.D. (Maria Dolores)
Novo, F.J. (Francisco Javier)
Calasanz-Abinzano, M.J. (Maria Jose)
Keywords: Chromosomes, Human, Pair 10/genetics
Chromosomes, Human, Pair 16/genetics
Leukemia, Monocytic, Acute/genetics
Nuclear Proteins/genetics
Oncogene Proteins, Fusion/genetics
Saccharomyces cerevisiae Proteins/genetics
Issue Date: 2003
Publisher: Wiley-Blackwell
Publisher version:
ISSN: 1098-2264
Citation: Vizmanos JL, Larrayoz MJ, Lahortiga I, Floristan F, Alvarez C, Odero MD, et al. t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia. Genes Chromosomes Cancer 2003 Apr;36(4):402-405.
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML.
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Appears in Collections:DA - CIMA - Oncología - Genética - Artículos de revista
DA - Ciencias - Genética - Artículos de revista

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