Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Beloqui, O. (Óscar) | - |
dc.creator | Colina, I. (Inmaculada) | - |
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.creator | Orbe, J. (Josune) | - |
dc.date.accessioned | 2011-11-28T11:18:22Z | - |
dc.date.available | 2011-11-28T11:18:22Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Paramo JA, Beloqui O, Colina I, Diez J, Orbe J. Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects. J Thromb Haemost 2005 Apr;3(4):662-664. | es_ES |
dc.identifier.issn | 1538-7933 | - |
dc.identifier.uri | https://hdl.handle.net/10171/19967 | - |
dc.description.abstract | Von Willebrand factor (VWF) is considered a reliable marker of endothelial damage. Plasma levels of VWF were measured in 857 middle-aged subjects (80.4% men) free of clinically overt atherosclerotic disease, in relation to cardiovascular risk factors, carotid intima-media thickness (IMT) and microalbuminuria, two established surrogate markers of atherosclerosis. There was linear trend for the increase of VWF, carotid IMT (p < 0.001) and microalbuminuria (p = 0.018). The association between VEF and both markers remained statistically significant after adjusting for cardiovascular risk factors and inflammatory markers (p < 0.01). In conclusion, VWF was independently associated with both structural and functional surrogates of atherosclerosis in asymptomatic subjects, thus representing a systemic biomarker of subclinical atherosclerosis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Von Willebrand factor | es_ES |
dc.subject | Atherosclerosis | es_ES |
dc.subject | Endothelial damage | es_ES |
dc.subject | Carotid intima-media thickness | es_ES |
dc.subject | Microalbuminuria | es_ES |
dc.title | Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1111/j.1538-7836.2005.01305.x | es_ES |
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