Full metadata record
DC Field | Value | Language |
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dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Orbe, J. (Josune) | - |
dc.creator | Beloqui, O. (Óscar) | - |
dc.creator | Benito-Boilos, A. (Alberto) | - |
dc.creator | Colina, I. (Inmaculada) | - |
dc.creator | Martinez-Vila, E. (Eduardo) | - |
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.date.accessioned | 2011-11-28T11:53:31Z | - |
dc.date.available | 2011-11-28T11:53:31Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Paramo JA, Orbe J, Beloqui O, Benito A, Colina I, Martinez-Vila E, et al. Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease. Stroke 2004 May;35(5):1085-1089. | es_ES |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | https://hdl.handle.net/10171/19976 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: Thrombin, a central enzyme in the clotting cascade, plays a role not only in thrombosis but also in the progression of atherosclerosis. We studied the relationship between prothrombin fragment 1+2 (F1+2), a specific marker of thrombin generation in vivo, and carotid intima-media thickness (IMT), an index of subclinical atherosclerosis. METHODS: We examined 181 asymptomatic middle-aged subjects (mean age 55.6 years, 76.7% men) free of overt clinical atherosclerotic disease. F1+2 was measured by enzyme-linked immunosorbent assay and IMT by duplex ultrasonography of carotid artery. Multiple linear regression analysis was used to assess the relationship between the 2 parameters. RESULTS: Compared with individuals in the lowest tertile of F1+2, those in the upper tertile (>0.55 nmol/L) showed significantly higher IMT (P<0.01). In correlation analysis, a positive relationship was found between plasma F1+2 and carotid IMT. F1+2 also correlated positively with cholesterol (P<0.008) and low-density lipoprotein cholesterol (P<0.005), but not with blood pressure or body mass index. In the multivariate analysis, the association of F1+2 with carotid IMT remained significant (P<0.001) after adjustment for age, sex, body mass index, systolic blood pressure, cholesterol, diabetes, and smoking. CONCLUSIONS: In a population sample of adults without clinically overt atherosclerotic disease, the plasma levels of F1+2 were significantly associated with carotid IMT, suggesting a relationship between thrombin generation and the development atherosclerosis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Heart Association, American Stroke Association | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Prothrombin | es_ES |
dc.subject | Atherosclerosis | es_ES |
dc.subject | Carotid arteries | es_ES |
dc.subject | Intima-media thickness | es_ES |
dc.subject | Thrombin | es_ES |
dc.title | Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1161/01.STR.0000124927.38723.f2 | es_ES |
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