Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Orbe, J. (Josune) | - |
dc.creator | Fernandez, J. (Javier) | - |
dc.date.accessioned | 2012-05-28T15:23:50Z | - |
dc.date.available | 2012-05-28T15:23:50Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Paramo JA, Orbe J, Fernandez J. Fibrinolysis/proteolysis balance in stable angina pectoris in relation to angiographic findings. Thromb Haemost 2001 Aug;86(2):636-639. | es_ES |
dc.identifier.issn | 0340-6245 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22250 | - |
dc.description.abstract | The plasma fibrinolytic/proteolytic balance was assessed in 60 stable angina patients who underwent control coronary catheterization and the results were correlated with angiographic findings and control samples (n = 20). The concentrations of t-PA, PAI-1, collagenase (MMP-1), tissue inhibitor of MMP (TIMP-1), plasmin-antiplasmin (PAP) complexes and alpha2-macroglobulin (alpha2-M) were measured in plasma samples. The results showed a significant increase of PAP (p <0.001) and a reduction of alpha2-M (p <0.001) in the group of patients when compared to controls, indicating a degree of fibrinolysis/proteolysis activation. There was no correlation between the different parameters analyzed and the extent of angiographically proven atherosclerosis (one or more stenotic vessels), while the t-PA levels were significantly elevated (p <0.03) in patients with coronary stenosis > or =75% or occlusion. We conclude that there is a disturbance of the plasma fibrinolysis/proteolysis in patients with stable angina not related to the extent of atherosclerosis. The t-PA levels may be a good marker for coronary occlusion in these patients. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Schattauer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Fibrinolysis | es_ES |
dc.subject | Proteolysis | es_ES |
dc.subject | Coronary disease | es_ES |
dc.subject | t-PA | es_ES |
dc.title | Fibrinolysis/proteolysis balance in stable angina pectoris in relation to angiographic findings | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://bit.ly/LBjVe1 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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