Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Nespereira, B. (Beatriz) | - |
dc.creator | Perez-Ilzarbe, M. (Maitane) | - |
dc.creator | Fernandez-Robredo, P. (Patricia) | - |
dc.creator | Fuentes, A.M. (Ángela M.) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Rodriguez, J.A. (José Antonio) | - |
dc.date.accessioned | 2012-05-28T15:39:35Z | - |
dc.date.available | 2012-05-28T15:39:35Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Nespereira B, Perez-Ilzarbe M, Fernandez P, Fuentes AM, Paramo JA, Rodriguez JA. Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice. Atherosclerosis 2003 Nov;171(1):67-73. | es_ES |
dc.identifier.issn | 1879-1484 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22258 | - |
dc.description.abstract | Anti-angiogenic therapy reduces both plaque growth and intimal neovascularization in apolipoprotein-E-deficient mice (apoE-/-). Vascular endothelial growth factor (VEGF) has been suggested as playing a role in the development of atherosclerosis. We examined the hypothesis that VEGF and VEGF receptor-2 (VEGFR-2) expression is upregulated in apoE-/- and, since it could be driven by oxidative stress, tested whether dietary supplementation with vitamins C and E could downregulate it.Two-month-old apoE-/- received vitamin C combined with alpha- or beta-tocopherol for 4 weeks. Aortic VEGF and VEGFR-2 expression were measured by RT-qPCR and western blot.ApoE-/- showed significantly higher expression of aortic VEGF and VEGFR-2 mRNA (P<0.001) and protein (P<0.001) than wild-type mice, as well as increased plasma VEGF (P<0.001). Vitamin C and alpha-tocopherol significantly reduced aortic VEGF and VEGFR-2 expression in apoE-/- (P<0.001), circulating VEGF (P<0.01) and plasma lipid peroxidation (P<0.01). apoE-/- receiving vitamin C and beta-tocopherol showed diminished lipid peroxidation and VEGFR-2, but only partial reduction of VEGF expression. These data demonstrate that augmented VEGF and VEGFR-2 expression in apoE-/- vasculature can be downregulated by vitamins C and E, at least partially through oxidative stress reduction. This novel mechanism could contribute to explaining the beneficial effects of antioxidant vitamins in experimental atherosclerosis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | VEGF | es_ES |
dc.subject | VEGFR-2 | es_ES |
dc.subject | Hypercholesterolemia | es_ES |
dc.subject | Ascorbic acid | es_ES |
dc.subject | Tocopherol | es_ES |
dc.title | Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0021915003003472 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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