Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Lopez, Y. (Yolanda) | - |
dc.creator | Paloma, M.J. (María José) | - |
dc.creator | Rifon, J. J. (Jose J.) | - |
dc.creator | Cuesta, B. (Braulia) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.date.accessioned | 2012-05-28T15:51:30Z | - |
dc.date.available | 2012-05-28T15:51:30Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Lopez Y, Paloma MJ, Rifon J, Cuesta B, Paramo JA. Measurement of prethrombotic markers in the assessment of acquired hypercoagulable states. Thromb Res 1999 Jan 15;93(2):71-78. | es_ES |
dc.identifier.issn | 1879-2472 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22269 | - |
dc.description.abstract | Hypercoagulable states can be detected by measuring activation peptides, enzyme-inhibitor complexes, and fibrin/fibrinogen degradation products, which are markers of hemostatic activation. A series of these prethrombotic markers has been evaluated in the elderly, pregnancy, diabetes and acute myocardial infarction patients (n=30 in each group) as well as in hematologic malignancies (n=42). The parameters assayed were: prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complexes (TAT), fibrinopeptide A (FPA), plasmin-alpha2 antiplasmin complexes (PAP) and D-Dimer. Results were compared with those obtained in a group of 30 healthy subjects. We found a significant increase of F1+2, TAT and FPA in elderly (p<0.05), acute myocardial infarction (AMI) (p<0.01), hematologic malignancies (p<0.01), and pregnancy (p<0.0001), indicating a marked clotting activation. Diabetic patients under strict metabolic control only presented a moderate increase of TAT (p<0.05), suggesting a slight activation. We also observed a highly significant elevation of PAP and D-Dimer in elderly (p<0.001), AMI (p<0.0001), and malignancy (p<0.0001), indicating an activation of the fibrinolytic system. The combination of selected fibrinolytic and coagulation measurements is useful for the detection of a hypercoagulable state in conditions characterized by a risk of thrombosis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Hypercoagulability | es_ES |
dc.subject | Elderly | es_ES |
dc.subject | Pregnancy | es_ES |
dc.subject | Diabetes | es_ES |
dc.subject | Myocardial infarction | es_ES |
dc.subject | Malignancy | es_ES |
dc.title | Measurement of prethrombotic markers in the assessment of acquired hypercoagulable states | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0049384898001650 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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