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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Colucci, M. (M.) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Collen, D. (D.) | - |
dc.date.accessioned | 2012-06-08T18:20:07Z | - |
dc.date.available | 2012-06-08T18:20:07Z | - |
dc.date.issued | 1985 | - |
dc.identifier.citation | Colucci M, Paramo JA, Collen D. Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation. J Clin Invest 1985 Mar;75(3):818-824. | es_ES |
dc.identifier.issn | 1558-8238 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22516 | - |
dc.description.abstract | Endotoxin producing bacteria cause disseminated intravascular coagulation (DIC); however, the mechanism of endotoxin action in man is still unclear. Impairment of the fibrinolytic system has been suggested as a contributing mechanism. A single injection of Escherichia coli lipopolysaccharide in rabbits resulted in a marked and prolonged increase of the levels of a fast-acting inhibitor of plasminogen activator (PA-inhibitor) in plasma (from 3.9 +/- 0.7 to 41 +/- 13.2 U/ml after 3 h). Gel filtration studies indicated that inhibition of human tissue-type plasminogen activator (t-PA) by rabbit plasma is accompanied by a change in the elution profile of the activator compatible with the formation of an enzyme-inhibitor complex with an apparent molecular weight of 100,000. Injection of human t-PA (1,500 IU/kg body wt) in endotoxin treated animals resulted in very fast inhibition of t-PA and formation of a similar complex. The half-life of circulating PA-inhibitor activity in rabbits was about 7 min as estimated by donor receiver plasma transfusion experiments. Stimulation of cultured human endothelial cells with endotoxin resulted in enhanced rate of accumulation of PA-inhibitor activity in the culture medium (two- to sevenfold increase). In five patients with septicemia, markedly increased levels of PA-inhibitor (14.3 +/- 15.5 U/ml) as compared with control subjects (1.3 +/- 0.7 U/ml) were observed in plasma. A very strong correlation (r = 0.98) was found between inhibition of t-PA and of urokinase in all conditions, suggesting that this fast-acting inhibitor reacts with both plasminogen activators. These data suggest that the appearance of this fast-acting PA-inhibitor is very sensitive to endotoxin stimulation. The marked increase in the level of PA-inhibitor in blood may contribute to the pathogenesis of DIC in septicemia. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Clinical Investigation | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Endotoxins/pharmacology | es_ES |
dc.subject | Glycoproteins/blood | es_ES |
dc.subject | Plasminogen activators/antagonists and inhibitors | es_ES |
dc.subject | Plasminogen inactivators | es_ES |
dc.title | Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.jci.org/75/3 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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