Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Colucci, M. (M.) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Stassen, J.M. (J.M.) | - |
dc.creator | Collen, D. (D.) | - |
dc.date.accessioned | 2012-07-19T12:01:01Z | - |
dc.date.available | 2012-07-19T12:01:01Z | - |
dc.date.issued | 1986 | - |
dc.identifier.citation | Colucci M, Paramo JA, Stassen JM, Collen D. Influence of the fast-acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue-type plasminogen activator in rabbits. Interference of tissue-derived components. J Clin Invest 1986 Jul;78(1):138-144. | es_ES |
dc.identifier.issn | 1558-8238 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22924 | - |
dc.description.abstract | The influence of endotoxin-induced elevated plasma levels of the fast-acting inhibitor of plasminogen activator (PA-inhibitor) on thrombolysis was investigated in rabbits with a jugular vein thrombus. Infusion of human tissue-type plasminogen activator (t-PA) produced similar degrees of thrombolysis in control and endotoxin-treated rabbits, although no free t-PA could be demonstrated in plasma of endotoxin-treated animals. Infusion of t-PA in an extracorporeal arteriovenous shunt resulted in loss of thrombolytic activity in endotoxin-treated animals but not in control animals. Blood clots superfused in vitro with mixtures of t-PA and normal plasma lysed in contrast to clots superfused with t-PA and PA-inhibitor-rich plasma. However, addition of rabbit lung slices to the plasma surrounding the blood clot, reversed the inhibition of thrombolysis by PA-inhibitor-rich plasma. This indicates that tissue-derived factor(s) are involved in the regulation of in vivo thrombolysis. These hypothetical factor(s) are, however, very unstable in plasma, which has thus far precluded their further characterization. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Clinical Investigation | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Fibrinolysis/drug effects | es_ES |
dc.subject | Glycoproteins/pharmacology | es_ES |
dc.subject | Tissue Plasminogen Activator/antagonists & inhibitors | es_ES |
dc.title | Influence of the fast-acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue-type plasminogen activator in rabbits. Interference of tissue-derived components | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.jci.org/78/1 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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