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Emergence of Secondary Acute Leukemia in a Patient Treated for Osteosarcoma: Implications of Germline TP53 Mutations
Authors: Panizo, C. (Carlos)
Patiño, A. (Ana)
Calasanz-Abinzano, M.J. (Maria Jose)
Rifon, J. (Jose)
Sierrasesumaga, L. (Luis)
Rocha, E. (Eduardo)
Keywords: Femoral Neoplasms/drug therapy/radiotherapy/surgery
Genes, Tumor Suppressor/drug effects/genetics
Leukemia, Myeloid, Acute/chemically induced/genetics
Issue Date: 1998
Publisher: Wiley-Blackwell
Publisher version:;2-F/pdf
ISSN: 0098-1532
Citation: Panizo C, Patiño A, Calasanz MJ, Rifón J, Sierrasesumaga L, Rocha E. Emergence of Secondary Acute Leukemia in a Patient Treated for Osteosarcoma: Implications of Germline TP53 Mutations. Med Pediatr Oncol. 1998 Mar;30(3):165-9.
Secondary leukemia and myelodysplastic syndromes have been reported in patients following treatment for a wide range of neoplastic disorders. However second malignancies after chemotherapy and/or irradiation for osteosarcoma are unusual. PROCEDURE: We report the case of a 15-year-old girl who developed a myelodysplastic syndrome with evolution to acute nonlymphocytic leukemia after treatment for osteosarcoma. Therapy-related acute leukemia karyotype findings such as abnormalities of chromosomes 5, 7, and 17 were found in the cytogenetic analysis. Moreover, using denaturing gradient gel electrophoresis and DNA sequencing, we detected the presence of a double germline mutation in exon 7 of the TP53 gene. CONCLUSION: This observation supports the possibility of a causal relationship between germline TP53 mutations and the development of secondary leukemia and myelodysplasia
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Appears in Collections:DA - CUN - Unidad de Genética clínica - Artículos de revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Pediatría - Artículos de revista

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