Angiogenic therapy for cardiac repair based on protein delivery systems
Keywords: 
Cardiovascular diseases
Cardiac repair
Growth factor
Angiogenesis
Protein delivery
Issue Date: 
2012
Publisher: 
Springer
ISSN: 
1382-4147
Citation: 
Formiga FR, Tamayo E, Simon-Yarza T, Pelacho B, Prosper F, Blanco-Prieto MJ. Angiogenic therapy for cardiac repair based on protein delivery systems. Heart Fail Rev 2012 May;17(3):449-473
Abstract
Cardiovascular diseases remain the first cause of morbidity and mortality in the developed countries and are a major problem not only in the western nations but also in developing countries. Current standard approaches for treating patients with ischemic heart disease include angioplasty or bypass surgery. However, a large number of patients cannot be treated using these procedures. Novel curative approaches under investigation include gene, cell, and protein therapy. This review focuses on potential growth factors for cardiac repair. The role of these growth factors in the angiogenic process and the therapeutic implications are reviewed. Issues including aspects of growth factor delivery are presented in relation to protein stability, dosage, routes, and safety matters. Finally, different approaches for controlled growth factor delivery are discussed as novel protein delivery platforms for cardiac regeneration.

Files in This Item:
File: 
Table 4Rocha.pdf
Description: 
Size: 
28,51 kB
Format: 
Adobe PDF
File: 
Table 3.pdf
Description: 
Size: 
67,2 kB
Format: 
Adobe PDF
File: 
Table 1Rocha.pdf
Description: 
Size: 
19,6 kB
Format: 
Adobe PDF
File: 
Revised Table 2-HERV-311.pdf
Description: 
Size: 
78,42 kB
Format: 
Adobe PDF
File: 
Revised Manuscript-HREV-311.pdf
Description: 
Size: 
263,32 kB
Format: 
Adobe PDF
File: 
Fig.1.pdf
Description: 
Size: 
111,98 kB
Format: 
Adobe PDF
File: 
Fig.2.pdf
Description: 
Size: 
54,56 kB
Format: 
Adobe PDF
File: 
Fig.3.pdf
Description: 
Size: 
63,84 kB
Format: 
Adobe PDF
File: 
Fig.4.pdf
Description: 
Size: 
146,01 kB
Format: 
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.