Gil A, Pabón A, Galiano S, Burguete A, Pérez-Silanes S, Deharo E, et al. Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents. Molecules 2014 Feb 18;19(2):2166-2180
We report the synthesis and antimalarial activities of eighteen quinoxaline and
quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds
1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.