Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
Keywords: 
Chalcone
Quinoxaline 1,4-di-N-oxide
Quinoxaline
Antimalarial agents
Plasmodium falciparum
Issue Date: 
18-Feb-2014
Publisher: 
MDPI (Molecular Diversity Preservation International)
ISSN: 
1420-3049
Citation: 
Gil A, Pabón A, Galiano S, Burguete A, Pérez-Silanes S, Deharo E, et al. Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents. Molecules 2014 Feb 18;19(2):2166-2180
Abstract
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.

Files in This Item:
File: 
molecules2014.pdf
Description: 
Size: 
257,12 kB
Format: 
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.