Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Gamazo, C. (Carlos) | - |
dc.creator | Ferrer-Cardona, M. (Marta) | - |
dc.creator | Sanz, M.L. (María Luisa) | - |
dc.creator | Gastaminza, G. (Gabriel) | - |
dc.creator | Camacho, A.I. (A.I.) | - |
dc.creator | Irache, J.M. (Juan Manuel) | - |
dc.creator | Souza, J. (Juliana) de | - |
dc.date.accessioned | 2014-11-15T19:06:32Z | - |
dc.date.available | 2014-11-15T19:06:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Souza J, Irache JM, Camacho AI, Gastaminza G, Sanz ML, Ferrer M, et al. Immunogenicity of peanut proteins containing poly (anhydride) nanoparticles. Clin Vaccine Immunol. 2014 Aug;21(8):1106-1112 | es_ES |
dc.identifier.issn | 1556-6811 | - |
dc.identifier.uri | https://hdl.handle.net/10171/37049 | - |
dc.description.abstract | In the last decade, peanut allergy has increased substantially. Significant differences in the prevalence among different countries are attributed to the type of thermal processing. In spite of the high prevalence and the severe reaction induced by peanuts, there is no immunotherapy available. The aim of this work was to evaluate the potential application of poly(anhydride) nanoparticles (NPs) as immunoadjuvants for peanut oral immunotherapy. NPs loaded with raw or roasted peanut proteins were prepared by a solvent displacement method and dried by either lyophilization or spray-drying. After physicochemical characterization, their adjuvant capacity was evaluated after oral immunization of C57BL/6 mice. All nanoparticle formulations induced a balanced T(H)1 and T(H)2 antibody response, accompanied by low specific IgE induction. In addition, oral immunization with spray-dried NPs loaded with peanut proteins was associated with a significant decrease in splenic T(H)2 cytokines (interleukin 4 [IL-4], IL-5, and IL-6) and enhancement of both T(H)1 (gamma interferon [IFN-γ]) and regulatory (IL-10) cytokines. In conclusion, oral immunization with poly(anhydride) NPs, particularly spray-dried formulations, led to a pro-T(H)1 immune response. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Microbiology | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Oral immunotherapy | es_ES |
dc.subject | Poly(anhydride) nanoparticles | es_ES |
dc.subject | Allergy | es_ES |
dc.subject | Peanut | es_ES |
dc.title | Immunogenicity of peanut proteins containing poly (anhydride) nanoparticles | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1128/CVI.00359-14 | es_ES |
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