Full metadata record
DC Field | Value | Language |
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dc.creator | Guasch-Ferre, M. (Marta) | - |
dc.creator | Bullo, M. (Monica) | - |
dc.creator | Costa, B. (Bernardo) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Ibarrola-Jurado, N. (Nuria) | - |
dc.creator | Estruch, R. (Ramón) | - |
dc.creator | Barrio, F. (Francisco) | - |
dc.creator | Salas-Salvado, J. (Jordi) | - |
dc.date.accessioned | 2014-11-24T11:07:23Z | - |
dc.date.available | 2014-11-24T11:07:23Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Guasch-Ferré M, Bulló M, Costa B, Martínez-Gonzalez MA, Ibarrola-Jurado N, Estruch R, et al. A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk. PLoS One. 2012;7(3):e33437. | es_ES |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10171/37085 | - |
dc.description.abstract | Abstract Introduction: To develop and test a diabetes risk score to predict incident diabetes in an elderly Spanish Mediterranean population at high cardiovascular risk. Materials and Methods: A diabetes risk score was derived from a subset of 1381 nondiabetic individuals from three centres of the PREDIMED study (derivation sample). Multivariate Cox regression model ß-coefficients were used to weigh each risk factor. PREDIMED-personal Score included body-mass-index, smoking status, family history of type 2 diabetes, alcohol consumption and hypertension as categorical variables; PREDIMED-clinical Score included also high blood glucose. We tested the predictive capability of these scores in the DE-PLAN-CAT cohort (validation sample). The discrimination of Finnish Diabetes Risk Score (FINDRISC), German Diabetes Risk Score (GDRS) and our scores was assessed with the area under curve (AUC). Results: The PREDIMED-clinical Score varied from 0 to 14 points. In the subset of the PREDIMED study, 155 individuals developed diabetes during the 4.75-years follow-up. The PREDIMED-clinical score at a cutoff of $6 had sensitivity of 72.2%, and specificity of 72.5%, whereas AUC was 0.78. The AUC of the PREDIMED-clinical Score was 0.66 in the validation sample (sensitivity = 85.4%; specificity = 26.6%), and was significantly higher than the FINDRISC and the GDRS in both the derivation and validation samples. Discussion: We identified classical risk factors for diabetes and developed the PREDIMED-clinical Score to determine those individuals at high risk of developing diabetes in elderly individuals at high cardiovascular risk. The predictive capability of the PREDIMED-clinical Score was significantly higher than the FINDRISC and GDRS, and also used fewer items in the questionnaire. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Life-style intervention | es_ES |
dc.subject | Identifying individuals | es_ES |
dc.subject | Glucose-tolerance | es_ES |
dc.subject | Physical-activity | es_ES |
dc.subject | Prevention | es_ES |
dc.subject | Questionnaire | es_ES |
dc.subject | Care | es_ES |
dc.subject | Validation | es_ES |
dc.subject | Project | es_ES |
dc.subject | Adults | es_ES |
dc.title | A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0033437 | es_ES |
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