Full metadata record
DC FieldValueLanguage
dc.creatorGuasch-Ferre, M. (Marta)-
dc.creatorBullo, M. (Mónica)-
dc.creatorCosta, B. (Bernardo)-
dc.creatorMartinez-Gonzalez, M.A. (Miguel Ángel)-
dc.creatorIbarrola-Jurado, N. (Nuria)-
dc.creatorEstruch, R. (Ramón)-
dc.creatorBarrio, F. (Francisco)-
dc.creatorSalas-Salvado, J. (Jordi)-
dc.date.accessioned2014-11-24T11:07:23Z-
dc.date.available2014-11-24T11:07:23Z-
dc.date.issued2012-
dc.identifier.citationGuasch-Ferré M, Bulló M, Costa B, Martínez-Gonzalez MA, Ibarrola-Jurado N, Estruch R, et al. A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk. PLoS One. 2012;7(3):e33437.es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10171/37085-
dc.description.abstractAbstract Introduction: To develop and test a diabetes risk score to predict incident diabetes in an elderly Spanish Mediterranean population at high cardiovascular risk. Materials and Methods: A diabetes risk score was derived from a subset of 1381 nondiabetic individuals from three centres of the PREDIMED study (derivation sample). Multivariate Cox regression model ß-coefficients were used to weigh each risk factor. PREDIMED-personal Score included body-mass-index, smoking status, family history of type 2 diabetes, alcohol consumption and hypertension as categorical variables; PREDIMED-clinical Score included also high blood glucose. We tested the predictive capability of these scores in the DE-PLAN-CAT cohort (validation sample). The discrimination of Finnish Diabetes Risk Score (FINDRISC), German Diabetes Risk Score (GDRS) and our scores was assessed with the area under curve (AUC). Results: The PREDIMED-clinical Score varied from 0 to 14 points. In the subset of the PREDIMED study, 155 individuals developed diabetes during the 4.75-years follow-up. The PREDIMED-clinical score at a cutoff of $6 had sensitivity of 72.2%, and specificity of 72.5%, whereas AUC was 0.78. The AUC of the PREDIMED-clinical Score was 0.66 in the validation sample (sensitivity = 85.4%; specificity = 26.6%), and was significantly higher than the FINDRISC and the GDRS in both the derivation and validation samples. Discussion: We identified classical risk factors for diabetes and developed the PREDIMED-clinical Score to determine those individuals at high risk of developing diabetes in elderly individuals at high cardiovascular risk. The predictive capability of the PREDIMED-clinical Score was significantly higher than the FINDRISC and GDRS, and also used fewer items in the questionnaire.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectLife-style interventiones_ES
dc.subjectIdentifying individualses_ES
dc.subjectGlucose-tolerancees_ES
dc.subjectPhysical-activityes_ES
dc.subjectPreventiones_ES
dc.subjectQuestionnairees_ES
dc.subjectCarees_ES
dc.subjectValidationes_ES
dc.subjectProjectes_ES
dc.subjectAdultses_ES
dc.titleA risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular riskes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0033437es_ES

Files in This Item:
File: 
A risk score.pdf
Description: 
Size: 
106,52 kB
Format: 
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.