Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Calleja, P. (Patricia) | - |
dc.creator | Espuelas, S. (Socorro) | - |
dc.creator | Corrales, L. (Leticia) | - |
dc.creator | Pio, R. (Rubén) | - |
dc.creator | Irache, J.M. (Juan Manuel) | - |
dc.date.accessioned | 2015-01-07T17:58:06Z | - |
dc.date.available | 2015-01-07T17:58:06Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Calleja P, Espuelas S, Corrales L, Pio R, Irache JM. Pharmacokinetics and antitumor efficacy of paclitaxel-cyclodextrin complexes loaded in mucus-penetrating nanoparticles for oral administration. Nanomedicine (Lond) 2014;9(14):2109-2121 | es_ES |
dc.identifier.issn | 1743-5889 | - |
dc.identifier.uri | https://hdl.handle.net/10171/37240 | - |
dc.description.abstract | The authors report a novel approach for enhancing the oral absorption of paclitaxel (PTX) by encapsulation in poly(anhydride) nanoparticles (NPs) containing cyclodextrins and poly(ethylene glycol). Materials & methods: Formulations were prepared using the solvent displacement method. Subsequently, pharmacokinetics and organ distribution assays were evaluated after oral administration into C57BL/6J mice. In addition, antitumor efficacy studies were performed in a subcutaneous tumor model of Lewis lung carcinoma. Results: PTX-loaded NPs displayed sizes between 190–300 nm. Oral NPs achieved drug plasma levels for at least 24 h, with an oral bioavailability of 55–80%. Organ distribution studies revealed that PTX, orally administered in NPs, underwent a similar distribution to intravenous Taxol® (Bristol-Myers-Squibb, NJ, USA). For in vivo antitumor assays, oral strategy maintained a slower tumor growth than intravenous Taxol. Conclusion: PTX orally administered in poly(anhydride) NPs, combined with cyclodextrins and poly(ethylene glycol), displayed sustained plasma levels and significant antitumor effect in a syngenic tumor model of carcinoma in mice. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Future Medicine | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Oral chemotherapy | es_ES |
dc.subject | Pharmacokinetics | es_ES |
dc.subject | Antitumor efficacy | es_ES |
dc.subject | Paclitaxel | es_ES |
dc.subject | Poly(anhydride) nanoparticles | es_ES |
dc.subject | Cyclodextrins | es_ES |
dc.subject | Poly(ethylene glycol) 2000 | es_ES |
dc.title | Pharmacokinetics and antitumor efficacy of paclitaxel-cyclodextrin complexes loaded in mucus-penetrating nanoparticles for oral administration | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.2217/nnm.13.199 | es_ES |
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