Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Becerril, S. (Sara) | - |
dc.creator | Rodriguez, A. (Amaia) | - |
dc.creator | Catalan, V. (Victoria) | - |
dc.creator | Ramirez, B. (Beatriz) | - |
dc.creator | Unamuno, X. (Xabier) | - |
dc.creator | Portincasa, P. (Piero) | - |
dc.creator | Gomez-Ambrosi, J. (Javier) | - |
dc.creator | Frühbeck, G. (Gema) | - |
dc.date.accessioned | 2021-11-11T09:34:44Z | - |
dc.date.available | 2021-11-11T09:34:44Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Becerril, S. (Sara); Rodriguez, A. (Amaia); Catalan, V. (Victoria); et al. "Functional relationship between leptin and nitric oxide in metabolism". Nutrients. 11 (9), 2019, 2129 | es_ES |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62536 | - |
dc.description.abstract | Leptin, the product of the ob gene, was originally described as a satiety factor, playing a crucial role in the control of body weight. Nevertheless, the wide distribution of leptin receptors in peripheral tissues supports that leptin exerts pleiotropic biological effects, consisting of the modulation of numerous processes including thermogenesis, reproduction, angiogenesis, hematopoiesis, osteogenesis, neuroendocrine, and immune functions as well as arterial pressure control. Nitric oxide (NO) is a free radical synthesized from L-arginine by the action of the NO synthase (NOS) enzyme. Three NOS isoforms have been identified: the neuronal NOS (nNOS) and endothelial NOS (eNOS) constitutive isoforms, and the inducible NOS (iNOS). NO mediates multiple biological effects in a variety of physiological systems such as energy balance, blood pressure, reproduction, immune response, or reproduction. Leptin and NO on their own participate in multiple common physiological processes, with a functional relationship between both factors having been identified. The present review describes the functional relationship between leptin and NO in different physiological processes. | es_ES |
dc.description.sponsorship | This work was supported by the Instituto de Salud Carlos III and fondos FEDER (PI16/00221, PI16/01217, PI17/02183, and PI17/02188) and by the Department of Health of Gobierno de Navarra (61/2014). CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the Instituto de Salud Carlos III, Spain. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Leptin | es_ES |
dc.subject | Nitric oxide | es_ES |
dc.subject | Nitric oxide synthase | es_ES |
dc.title | Functional relationship between leptin and nitric oxide in metabolism | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.identifier.doi | 10.3390/nu11092129 | - |
dadun.citation.number | 9 | es_ES |
dadun.citation.publicationName | Nutrients | es_ES |
dadun.citation.startingPage | 2129 | es_ES |
dadun.citation.volume | 11 | es_ES |
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