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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Landecho, M.F. (Manuel F.) | - |
dc.creator | Marín-Oto, M. (Marta) | - |
dc.creator | Recalde-Zamacona, B. (Borja) | - |
dc.creator | Bilbao, I. (Idoia) | - |
dc.creator | Frühbeck, G. (Gema) | - |
dc.date.accessioned | 2022-04-26T10:13:54Z | - |
dc.date.available | 2022-04-26T10:13:54Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Landecho, M.F. (Manuel F.); Marín-Oto, M. (Marta); Recalde-Zamacona, B. (Borja); et al. "Obesity as an adipose tissue dysfunction disease and a risk factor for infections – Covid-19 as a case study". European Journal of Internal Medicine. (91), 2021, 3 - 9 | es_ES |
dc.identifier.issn | 0953-6205 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63425 | - |
dc.description.abstract | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also expressed in adipose tissue. Moreover, adipose tissue is also a source of many proinflammatory mediators and adipokines that might enhance the characteristic COVID-19 cytokine storm due to a chronic low-grade inflammatory preconditioning. Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance | es_ES |
dc.description.sponsorship | This work was supported by Fondo de Investigación Sanitaria-FEDER (FIS PI19/00785) from the Spanish Instituto de Salud Carlos III. CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn) is an initiative of the Instituto de Salud Carlos III, Spain. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | COVID-19 | es_ES |
dc.subject | Cytokine storm | es_ES |
dc.subject | Adipokines | es_ES |
dc.subject | Leptin | es_ES |
dc.subject | Adiponectin | es_ES |
dc.subject | ARDS | es_ES |
dc.subject | Mortality | es_ES |
dc.subject | Diabetes mellitus | es_ES |
dc.subject | Bariatric surgery | es_ES |
dc.subject | Hypertension | es_ES |
dc.title | Obesity as an adipose tissue dysfunction disease and a risk factor for infections – Covid-19 as a case study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the CC license | es_ES |
dc.identifier.doi | 10.1016/j.ejim.2021.03.031 | - |
dadun.citation.endingPage | 9 | es_ES |
dadun.citation.number | 91 | es_ES |
dadun.citation.publicationName | European Journal of Internal Medicine | es_ES |
dadun.citation.startingPage | 3 | es_ES |
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