Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Rubio-Hernández, M. (Mercedes) | - |
dc.creator | Alcolea-Devesa, V. (Verónica) | - |
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.date.accessioned | 2022-06-14T07:54:12Z | - |
dc.date.available | 2022-06-14T07:54:12Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Rubio-Hernández, M. (Mercedes); Alcolea-Devesa, V. (Verónica); Pérez-Silanes, S. (Silvia). "Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs". Acta Tropica. 233, 2022, 106547 | es |
dc.identifier.issn | 0001-706X | - |
dc.identifier.uri | https://hdl.handle.net/10171/63644 | - |
dc.description.abstract | Current treatment for Chagas disease is based on only two drugs: benznidazole and nifurtimox. Compounds containing sulfur (S) in their structure have shown promising results in vitro and in vivo against Trypanosoma cruzi, the parasite causing Chagas disease. Notably, some reports show that the isosteric replacement of S by selenium (Se) could be an interesting strategy for the development of new compounds for the treatment of Chagas disease. To date, the activity against T. cruzi of three Se- containing groups has been compared with their S counterparts: selenosemicarbazones, selenoquinones, and selenocyanates. More studies are needed to confirm the positive results of Se compounds. Therefore, we have investigated S compounds described in the literature tested against T. cruzi. We focused on those tested in vivo that allowed isosteric replacement to propose their Se counterparts as promising compounds for the future development of new drugs against Chagas disease. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Chagas disease | es_ES |
dc.subject | Trypanosoma cruzi | es_ES |
dc.subject | Selenium | es_ES |
dc.subject | Sulfur | es_ES |
dc.subject | Bioisosterism | es_ES |
dc.subject | In vivo | es_ES |
dc.title | Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the CC BY-NC-ND license | es_ES |
dc.identifier.doi | 10.1016/j.actatropica.2022.106547 | - |
dadun.citation.publicationName | Acta Tropica | es_ES |
dadun.citation.startingPage | 106547 | es_ES |
dadun.citation.volume | 233 | es_ES |
Ficheros en este ítem:
Estadísticas e impacto
Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.