Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels during Wound Healing and Lymphedema

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Citation:

Beerens, M. (Manu); Aranguren, X.L. (Xabier L.); Hendrickx, B. (B.); et al. "Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels during Wound Healing and Lymphedema". Scientific reports. 8, 2018, 3852

Abstract

Lymphatic capillary growth is an integral part of wound healing, yet, the combined efectiveness of stem/progenitor cells on lymphatic and blood vascular regeneration in wounds needs further exploration. Stem/progenitor cell transplantation also emerged as an approach to cure lymphedema, a condition caused by lymphatic system defciency. While lymphedema treatment requires lymphatic system restoration from the capillary to the collector level, it remains undetermined whether stem/ progenitor cells support a complex regenerative response across the entire anatomical spectrum of the system. Here, we demonstrate that, although multipotent adult progenitor cells (MAPCs) showed potential to diferentiate down the lymphatic endothelial lineage, they mainly trophically supported lymphatic endothelial cell behaviour in vitro. In vivo, MAPC transplantation supported blood vessel and lymphatic capillary growth in wounds and restored lymph drainage across skin faps by stimulating capillary and pre-collector vessel regeneration. Finally, human MAPCs mediated survival and functional reconnection of transplanted lymph nodes to the host lymphatic network by improving their (lymph) vascular supply and restoring collector vessels. Thus, MAPC transplantation represents a promising remedy for lymphatic system restoration at diferent anatomical levels and hence an appealing treatment for lymphedema. Furthermore, its combined efcacy on lymphatic and blood vascular growth is an important asset for wound healing.

URI:

https://hdl.handle.net/10171/65873

DOI:

10.1038/s41598-018-21610-8

Appears in Collections:

DA - CUN - Hematología y Hemoterapia - Artículos de revista

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