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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Figueroa, R. (Rocío) | - |
dc.creator | Rampotas, A. (Alexandros) | - |
dc.creator | Halperin, D. (Daniel) | - |
dc.creator | Worth, T. (Tina) | - |
dc.creator | Vidler, J. (Jennifer) | - |
dc.creator | Melotti, D. (Dario) | - |
dc.creator | Ferguson, J.P. (John-Paul) | - |
dc.creator | Elmusharaf, N. (Nagah) | - |
dc.creator | Preston, G. (Gavin) | - |
dc.creator | Furtado, M. (Michelle) | - |
dc.creator | Dungarwalla, M. (Moez) | - |
dc.creator | Gohill, S.(Satyen) | - |
dc.creator | Patten, P. (Piers) | - |
dc.creator | Kennedy, B. (Ben) | - |
dc.creator | Eyre, T.A. (Toby A.) | - |
dc.creator | Schuh, A. (Anna) | - |
dc.creator | Fox, C. P. (Christopher P.) | - |
dc.creator | Munir, T. (Tahla) | - |
dc.creator | Martinez-Calle, N. (Nicolas) | - |
dc.date.accessioned | 2024-01-23T10:46:25Z | - |
dc.date.available | 2024-01-23T10:46:25Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Figueroa, R. (Rocío); Rampotas, A. (Alexandros); Halperin, D. (Daniel); et al. "Venetoclax ramp-up strategies for chronic lymphocytic leukaemia in the United Kingdom: a real world multicentre retrospective study". British Journal of Haematology. 202 (1), 2023, 48 - 53 | es_ES |
dc.identifier.issn | 1365-2141 | - |
dc.identifier.uri | https://hdl.handle.net/10171/68483 | - |
dc.description.abstract | This retrospective, observational study evaluated patterns of inpatient versus outpatient tumour lysis syndrome (TLS) monitoring during venetoclax ramp-up in 170 patients with chronic lymphocytic leukaemia. The primary outcome was clinical/biochemical TLS. Two clinical and four biochemical TLS occurred (4.1%). Five of the six events occurred in high-risk patients, four occurred at 20 mg dose and three at the 6-h time-point. Inpatient versus outpatient TLS rates within the high-risk subgroup were 15% and 8%. Risk category was the only predictor of TLS events in multivariate analysis. Outpatient escalation did not associate with clinically meaningful TLS events, suggesting outpatient escalation has manageable associated TLS risks, including in high-risk cohorts. These observations require confirmation in larger studies. | es_ES |
dc.description.sponsorship | This study was undertaken as a NHS service evaluation project | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Venetoclax | es_ES |
dc.subject | Chronic lymphocytic leukaemia | es_ES |
dc.subject | Dose ramp-up | es_ES |
dc.subject | Tumour lysis syndrome | es_ES |
dc.title | Venetoclax ramp-up strategies for chronic lymphocytic leukaemia in the United Kingdom: a real world multicentre retrospective study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License | es_ES |
dc.identifier.doi | 10.1111/bjh.18738 | - |
dadun.citation.endingPage | 53 | es_ES |
dadun.citation.number | 1 | es_ES |
dadun.citation.publicationName | British Journal of Haematology | es_ES |
dadun.citation.startingPage | 48 | es_ES |
dadun.citation.volume | 202 | es_ES |
dc.identifier.pmid | 36951278 | - |
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