Thermal characterization and stability evaluation of leishmanicidal selenocyanate and diselenide derivatives

Abstract

In this study, the thermal behavior of a series of leishmanicidal selenocyanate and diselenide biological active compounds has been studied by means of diferential scanning calorimetry, X-ray difraction and thermogravimetry in order to establish thermal stability criteria and investigate their polymorphism. Moreover, stability under acid, alkaline and oxidative media was tested using high-performance liquid chromatography with fuorescence detection. The results of the experiments show that there are fve types of polymorphic behaviors for the studied compounds. In addition, relationship is found among stability and a series of structural efects and stress conditions of compounds.