Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Arina, A. (Ainhoa) | - |
dc.creator | Murillo, O. (Oihana) | - |
dc.creator | Dubrot, J. (Juan) | - |
dc.creator | Azpilicueta, A. (Arantza) | - |
dc.creator | Alfaro, C. (Carlos) | - |
dc.creator | Perez-Gracia, J.L. (Jose Luis) | - |
dc.creator | Bendandi, M. (Maurizio) | - |
dc.creator | Palencia, B. (Belén) | - |
dc.creator | Hervas-Stubbs, S. (Sandra) | - |
dc.creator | Melero, I. (Ignacio) | - |
dc.date.accessioned | 2011-07-04T08:18:16Z | - |
dc.date.available | 2011-07-04T08:18:16Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Arina A, Murillo O, Dubrot J, Azpilikueta A, Alfaro C, Pérez-Gracia JL, et al. Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer. Expert Opin Biol Ther 2007 May;7(5):599-615. | es_ES |
dc.identifier.issn | 1744-7682 | - |
dc.identifier.uri | https://hdl.handle.net/10171/18715 | - |
dc.description.abstract | There is compelling evidence for the role of natural killer (NK) cells in tumor immunosurveillance and their beneficial effects on many experimentally successful immunotherapy strategies. NK cells mediate cell contact-dependent cellular cytotoxicity and produce pro-inflammatory cytokines, but do not rearrange antigen receptors. Their activation depends on various germline-encoded receptors, including CD16, which mediates recognition of antibody-coated target cells. NK cytotoxicity is checked by a repertoire of inhibitory receptors that scan adequate expression of major histocompatibility complex class I molecules on the potential target cell. Functional cross-talk of NK and dendritic cells suggests a critical role for NK cells in the initiation and regulation of cellular immunity. Considerable knowledge on the molecular basis of NK recognition/activation contrasts with a lack of successful translational research on these matters. However, there is plenty of opportunity for targeted intervention of inhibitory/activatory surface receptors and for adoptive cell therapy with autologous or allogeneic NK cells. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Informa Healthcare | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Neoplasms/immunology | es_ES |
dc.subject | Neoplasms/therapy | es_ES |
dc.subject | T-Lymphocytes/immunology | es_ES |
dc.title | Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://informahealthcare.com/doi/abs/10.1517/14712598.7.5.599 | es_ES |
Files in This Item:
There are no files associated with this item.
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.