Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

Berrade, L. (Luis); Aisa, B. (Bárbara); Ramirez, M.J. (María Javier); Galiano, S. (Silvia); Guccione, S. (S.); Moltzau, L.R. (Lise Roman); Levy, F.O. (Finn Olav); Nicoletti, F. (Ferdinando); Battaglia, G. (G.); Molinaro, G. (Gemma); Aldana, I. (Ignacio); Monge, A. (Antonio); Pérez-Silanes, S. (Silvia)

Keywords:

Depression
Benzo[b]thiophene
Serotonin
5-HT7 receptors
SERT
Dual compounds
Forced swimming test
Fluoxetine

Issue Date:

2011

Publisher:

American Chemical Society

ISSN:

0022-2623

Citation:

Berrade L, Aisa B, Ramirez MJ, Galiano S, Guccione S, Moltzau LR, et al. Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. J Med Chem 2011 Apr 28;54(8):3086-3090.

Abstract

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

URI:

https://hdl.handle.net/10171/18726

DOI:

http://dx.doi.org/10.1021/jm2000773

Appears in Collections:

DA - CIFA - I+D de medicamentos - Artículos de revistas
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista
DA - Farmacia - Farmacología - Artículos de revista
DA - Farmacia - Orgánica - Artículos de revista

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