Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Puig-Kröger, A. (Amaya) | |
dc.creator | Sanchez-Elsner, T. (Tilman) | |
dc.creator | Ruiz, N. (Natividad) | |
dc.creator | Andreu, E.J. (Enrique José) | |
dc.creator | Prosper-Cardoso, F. (Felipe) | |
dc.creator | Jensen, U.B. (U. B.) | |
dc.creator | Gil, J. (Juana) | |
dc.creator | Erickson, P. (P.) | |
dc.creator | Drabkin, H. (H.) | |
dc.creator | Groner, Y. (Y.) | |
dc.creator | Corbi, A.L. (Angel L.) | |
dc.date.accessioned | 2011-07-04T18:20:38Z | - |
dc.date.available | 2011-07-04T18:20:38Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Puig-Kröger, A., Sanchez-Elsner, T., Ruiz, N., Andreu, E. J., Prosper, F.,Jensen, U. B. et al. RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements. Blood 2003; 102 (9): 3252-3261 | es_ES |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | https://hdl.handle.net/10171/18733 | - |
dc.description.abstract | The CD11a/CD18 (leukocyte functionassociated antigen 1 [LFA-1]) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses. The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid cells depends on a functional RUNX1/AML-1–binding site (AML-110) within the MS7 sequence. We now report that MS7 contains a C/EBPbinding site (C/EBP-100), which overlaps with AML-110 and is bound by C/EBP factors in myeloid cells. C/EBP and RUNX/ AML factors compete for binding to their respective cognate elements and bind to the CD11a promoter MS7 sequence in a cell lineage- and differentiation-dependent manner. In myeloid cells MS7 is primarily recognized by C/EBP factors in proliferating cells whereas RUNX/AMLfactors (especially RUNX3/AML-2) bind to MS7 in differentiated cells. RUNX3/AML-2 binding to the CD11a promoter correlates with increased RUNX3/AML-2 protein levels and enhanced CD11a/CD18 cell surface expression. The relevance of the AML-110 element is underscored by the ability of AML-1/ETO to inhibit CD11a promoter activity, thus explaining the low CD11a/CD18 expression in t(8;21)–containing myeloid leukemia cells. Therefore, the expression of the CD11a/CD18 integrin in myeloid cells is determined through the differential occupancy of the CD11a proximal promoter by transcription factors implicated in the pathogenesis of myeloid leukemia. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society of Hematology | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Oncología | es_ES |
dc.title | RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1182/blood-2003-02-0618 | es_ES |
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