Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Beloqui, O. (Óscar) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Orbe, J. (Josune) | - |
dc.creator | Benito-Boilos, A. (Alberto) | - |
dc.creator | Colina, I. (Inmaculada) | - |
dc.creator | Monasterio, A. (Alberto) | - |
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.date.accessioned | 2011-11-16T12:43:56Z | - |
dc.date.available | 2011-11-16T12:43:56Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Beloqui O, Paramo JA, Orbe J, Benito A, Colina I, Monasterio A, at al. Monocyte cyclooxygenase-2 overactivity: a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors?. Eur Heart J 2005 Jan;26(2):153-158. | es_ES |
dc.identifier.issn | 0195-668X | - |
dc.identifier.uri | https://hdl.handle.net/10171/19838 | - |
dc.description.abstract | AIMS: Cyclooxygenase-2 (COX-2)-mediated prostaglandin production by activated macrophages is associated with inflammation and atherosclerosis. We investigated the relationship between COX-2-mediated prostaglandin-E2 (PGE2) release, cardiovascular risk factors, and carotid atherosclerosis in apparently healthy subjects. METHODS AND RESULTS: PGE2 release by lipopolysaccharide-stimulated blood monocytes was measured by ELISA in 291 subjects (76.5% men, mean age 58) who underwent global vascular risk assessment and carotid ultrasonography. COX-2 expression (real-time RT-PCR) was analysed in a subgroup of 100 subjects (76% men, mean age 59). Inducible PGE2 production was associated with smoking and diabetes (P<0.05), but not with arterial hypertension, dyslipidaemia, or obesity. Subjects in the highest tertile of PGE2 (>8.1 ng/mL) had significantly higher mean carotid intima-media thickness (IMT) than those in the lowest tertile (P<0.01). No significant differences among tertiles were observed in the levels of inflammatory markers (C-reactive protein, fibrinogen, and von Willebrand factor). The association between PGE2 and carotid IMT remained statistically significant (P=0.012) after adjustment for a number of cardiovascular and inflammatory risk factors. A correlation between COX-2 expression and PGE2 production was observed (P<0.005). CONCLUSIONS: COX-2-mediated PGE2 overproduction by stimulated monocytes might provide a new marker of subclinical atherosclerosis in asymptomatic subjects exposed to cardiovascular risk factors. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press (OUP) | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Cyclooxygenase | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Atherosclerosis | es_ES |
dc.subject | Cardiovascular risk | es_ES |
dc.subject | Carotid ultrasonography | es_ES |
dc.title | Monocyte cyclooxygenase-2 overactivity: a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors? | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1093/eurheartj/ehi016 | es_ES |
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