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dc.creatorRodriguez-Perez, A.I. (Ana I.)
dc.creatorValenzuela, R. (Rita)
dc.creatorVillar, B. (Begoña)
dc.creatorGuerra, M.J. (M. J.)
dc.creatorLanciego, J.L. (José Luis)
dc.creatorLabandeira-Garcia, J.L. (José L.)
dc.date.accessioned2011-11-17T10:02:36Z-
dc.date.available2011-11-17T10:02:36Z-
dc.date.issued2010-
dc.identifier.citationRodriguez-Perez AI, Valenzuela R, Villar-Cheda B, Guerra MJ, Lanciego JL, Labandeira-Garcia JL. Estrogen and angiotensin interaction in the substantia nigra. Relevance to postmenopausal Parkinson's disease. Exp Neurol 2010 Aug;224(2):517-526.es_ES
dc.identifier.issn1090-2430-
dc.identifier.urihttps://hdl.handle.net/10171/19862-
dc.description.abstractEpidemiological studies have reported that the incidence of Parkinson's disease (PD) is higher in postmenopausal than in premenopausal women of similar age. Several laboratory observations have revealed that estrogen has protective effects against dopaminergic toxins. The mechanism by which estrogen protects dopaminergic neurons has not been clarified, although estrogen-induced attenuation of the neuroinflammatory response plays a major role. We have recently shown that activation of the nigral renin-angiotensin system (RAS), via type 1 (AT1) receptors, leads to NADPH complex and microglial activation and induces dopaminergic neuron death. In the present study we investigated the effect of ovariectomy and estrogen replacement on the nigral RAS and on dopaminergic degeneration induced by intrastriatal injection of 6-OHDA. We observed a marked loss of dopaminergic neurons in ovariectomized rats treated with 6-OHDA, which was significantly reduced by estrogen replacement or treatment with the AT1 receptor antagonist candesartan. We also observed that estrogen replacement induces significant downregulation of the activity of the angiotensin converting enzyme as well as downregulation of AT1 receptors, upregulation of AT2 receptors and downregulation of the NADPH complex activity in the substantia nigra in comparison with ovariectomized rats. The present results suggest that estrogen-induced down-regulation of RAS and NADPH activity may be associated with the reduced risk of PD in premenopausal women, and increased risk in conditions causing early reduction in endogenous estrogen, and that manipulation of brain RAS system may be an efficient approach for the prevention or coadjutant treatment of PD in estrogen-deficient women.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/closedAccess-
dc.subjectAngiotensines_ES
dc.subjectDopaminees_ES
dc.subjectEstrogenes_ES
dc.subjectMenopausees_ES
dc.subjectNADPHes_ES
dc.subjectNeuroinflammationes_ES
dc.subjectNeuroprotectiones_ES
dc.subjectParkinsones_ES
dc.subjectReplacement therapyes_ES
dc.titleEstrogen and angiotensin interaction in the substantia nigra. Relevance to postmenopausal Parkinson's diseasees_ES
dc.typeArticuloes_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0014488610001925es_ES

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