Full metadata record
DC Field | Value | Language |
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dc.creator | Lopez-Salazar, M.B. (María Begoña) | - |
dc.creator | Gonzalez, A. (Arantxa) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.creator | Diaz-Dorronsoro, I. (Inés) | - |
dc.creator | Barba, J. (Joaquín) | - |
dc.creator | Tomas, L. (Lourdes) | - |
dc.creator | Lozano, E. (Elisa) | - |
dc.creator | Serrano, M. (Manuel) | - |
dc.creator | Varo-Cenarruzabeitia, M.N. (Miren Nerea) | - |
dc.creator | Beloqui, O. (Óscar) | - |
dc.creator | Fortuño, M.A. (María Antonia) | - |
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.date.accessioned | 2011-11-23T11:42:09Z | - |
dc.date.available | 2011-11-23T11:42:09Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Lopez B, Gonzalez A, Lasarte JJ, Sarobe P, Borras F, Diaz A, et al. Is plasma cardiotrophin-1 a marker of hypertensive heart disease?. J Hypertens 2005 Mar;23(3):625-632. | es_ES |
dc.identifier.issn | 0263-6352 | - |
dc.identifier.uri | https://hdl.handle.net/10171/19914 | - |
dc.description.abstract | OBJECTIVE: This study was designed to investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, is related to hypertensive heart disease, as defined by the presence of echocardiographically assessed left ventricular hypertrophy (LVH). METHODS: The study was performed in 31 normotensive subjects and 111 patients with never-treated essential hypertension (54 without LVH and 57 with LVH). Causes of LVH other than hypertension were excluded after a complete medical workup. A novel enzyme-linked immunosorbent assay was developed to measure plasma CT-1. RESULTS: Plasma CT-1 was increased (P < 0.001) in hypertensives compared with normotensives. The value of CT-1 was higher (P < 0.001) in hypertensives with LVH than in hypertensives without LVH. Some 31% of patients without LVH exhibited values of CT-1 above the upper normal limit in normotensives. A direct correlation was found between CT-1 and left ventricular mass index (r = 0.319, P < 0.001) in all subjects. Receiver operating characteristic curves showed that a cutoff of 39 fmol/ml for CT-1 provided 75% specificity and 70% sensitivity for predicting LVH with a relative risk of 6.21 (95% confidence interval, 2.95 to 13.09). CONCLUSIONS: These results show an association between LVH and the plasma concentration of CT-1 in essential hypertension. Although preliminary, these findings suggest that the determination of CT-1 may be an easy and reliable method for the initial screening and diagnosis of hypertensive heart disease. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott, Williams & Wilkins | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Cardiotrophin-1 | es_ES |
dc.subject | Hypertensive heart disease | es_ES |
dc.subject | Left ventricular | es_ES |
dc.title | Is plasma cardiotrophin-1 a marker of hypertensive heart disease? | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://journals.lww.com/jhypertension/Abstract/2005/03000/Is_plasma_cardiotrophin_1_a_marker_of_hypertensive.24.aspx | es_ES |
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