Full metadata record
DC Field | Value | Language |
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dc.creator | Laviades, C. (Concepción) | - |
dc.creator | Varo-Cenarruzabeitia, M.N. (Miren Nerea) | - |
dc.creator | Fernandez, J. (Javier) | - |
dc.creator | Mayor, G. (Gaspar) | - |
dc.creator | Gil, M.J. (María José) | - |
dc.creator | Monreal, J.I. (José Ignacio) | - |
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.date.accessioned | 2011-12-02T13:59:15Z | - |
dc.date.available | 2011-12-02T13:59:15Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Laviades C, Varo N, Fernandez J, Mayor G, Gil MJ, Monreal I, et al. Abnormalities of the extracellular degradation of collagen type I in essential hypertension. Circulation 1998 Aug 11;98(6):535-540. | es_ES |
dc.identifier.issn | 0009-7322 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20102 | - |
dc.description.abstract | BACKGROUND: This study was designed to investigate whether collagen type I degradation is altered in patients with essential hypertension and whether this alteration could be related to disturbances in the serum matrix metalloproteinase pathway of collagen degradation. A second aim of the study was to assess whether some relation exists between serum markers of collagen type I degradation and left ventricular hypertrophy in hypertensive patients. METHODS AND RESULTS: We measured serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP) as a marker of extracellular collagen type I degradation, of total matrix metalloproteinase-1 (MMP-1), or collagenase, of total tissue inhibitor of metalloproteinases 1 (TIMP-1), and of MMP-1/TIMP-1 complex in 37 patients with never-treated essential hypertension and in 23 normotensive control subjects. Serum concentrations of free MMP-1 and free TIMP-1 were calculated by subtracting the values of MMP-1/TIMP-1 complex from the values of total MMP-1 and total TIMP-1, respectively. Measurements were repeated in 26 hypertensive patients after 1 year of treatment with the ACE inhibitor lisinopril. Baseline free MMP-1 was decreased (P<0.001) and baseline free TIMP-1 was increased (P<0.001) in hypertensives compared with normotensives. No significant differences were observed in the baseline values of CITP between the 2 groups of subjects. Hypertensive patients with baseline left ventricular hypertrophy exhibited lower values of free MMP-1 (P<0.01) and CITP (P<0.05) and higher (P<0.001) values of free TIMP-1 than hypertensive patients without baseline left ventricular hypertrophy. Treated patients attained an increase (P<0.001) in free MMP-1 and a decrease (P<0.05) in free TIMP-1. In addition, serum CITP was increased (P<0.05) in treated hypertensives compared with normotensive subjects. CONCLUSIONS: These findings suggest that systemic extracellular degradation of collagen type I is depressed in patients with essential hypertension and can be normalized by treatment with lisinopril. A depressed degradation of collagen type I may facilitate organ fibrosis in hypertensive patients, namely, in those with left ventricular hypertrophy. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American heart association | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Collagen | es_ES |
dc.subject | Hypertension | es_ES |
dc.subject | Metalloproteinases | es_ES |
dc.subject | Peptides | es_ES |
dc.subject | Remodeling | es_ES |
dc.title | Abnormalities of the extracellular degradation of collagen type I in essential hypertension | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1161/01.CIR.98.6.535 | es_ES |
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