Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Marcos, B. (Beatriz) | - |
dc.creator | Garcia-Alloza, M. (Mónica) | - |
dc.creator | Gil-Bea, F.J. (Francisco J.) | - |
dc.creator | Chuang, T.T. (Tsu T.) | - |
dc.creator | Francis, P.T. (Paul T.) | - |
dc.creator | Chen, C.P. (Christopher P.) | - |
dc.creator | Tsang, S.W.T.Y. (Shirley W.T.Y.) | - |
dc.creator | Lai, M.K. (Mitchell K.) | - |
dc.creator | Ramirez, M.J. (María Javier) | - |
dc.date.accessioned | 2011-12-19T09:16:21Z | - |
dc.date.available | 2011-12-19T09:16:21Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Marcos B, Garcia-Alloza M, Gil-Bea FJ, Chuang TT, Francis PT, Chen CP, et al. Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease. J Alzheimers Dis 2008 May;14(1):43-50. | es_ES |
dc.identifier.issn | 1875-8908 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20227 | - |
dc.description.abstract | We studied the hypothesis that disturbances in 5-HT_{6} receptor function in the temporal cortex may contribute to clinical symptoms of Alzheimer's disease (AD). 5-HT_{6} density and 5-HT levels were significantly decreased in a cohort of AD patients prospectively assessed for cognitive/behavioral symptoms. cAMP formation after stimulation with the selective 5-HT_{6} receptor agonist E-6801 was significantly lower (p<0.01) in AD (170.02 +/- 27.53 pmol/mg prot.) compared to controls (823.33 +/-196.67). In addition, the ratio cAMP formation after stimulation with E-6801/5-HT_{6} receptor density was significantly lower (p< 0.01) in AD (6.67 +/- 0.83) compared to controls (16.67 +/- 3.33). Splitting these results by sex, 5-HT_{6} receptor activation was significantly lower (p< 0.01) in AD females compared to males (121.67 +/- 30.02 vs. 231.67 +/- 34.17 pmol/mg prot). 5-HT_{6} density and 5-HT levels were significantly correlated (p < or = 0.01) in both controls and AD patients, although in AD, this correlation was lost in females. Psychosis factor was the best predictor of reduced 5-HT levels or adenylate cyclase activity after E-6801 stimulation, the former result being due to females. It may be suggested that psychotic symptoms may be related to a dysregulation of 5-HT_{6} activation by 5-HT in the temporal cortex. These results are discussed in terms of purported influence of sex and therapeutical approaches to psychosis in AD. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Ios Press | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Adenylate cyclase | es_ES |
dc.subject | Gender | es_ES |
dc.subject | Neocortex | es_ES |
dc.subject | Psychosis | es_ES |
dc.title | Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.swetswise.com/eAccess/viewAbstract.do?articleID=37117018&titleID=110691 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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