Mazo M, Arana M, Pelacho B, Prosper F. Mesenchymal stem cells and cardiovascular disease: a bench to bedside roadmap. Stem Cells Int 2012;2012:175979.
In recent years, the incredible boost in stem cell research has kindled the
expectations of both patients and physicians. Mesenchymal progenitors, owing to
their availability, ease of manipulation, and therapeutic potential, have become
one of the most attractive options for the treatment of a wide range of diseases,
from cartilage defects to cardiac disorders. Moreover, their immunomodulatory
capacity has opened up their allogenic use, consequently broadening the
possibilities for their application. In this review, we will focus on their use
in the therapy of myocardial infarction, looking at their characteristics, in
vitro and in vivo mechanisms of action, as well as clinical trials.