Full metadata record
DC Field | Value | Language |
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dc.creator | Rincon-Mayans, A. (Anibal) | - |
dc.creator | Rosell, D. (David) | - |
dc.creator | Zudaire-Bergera, J.J. (Juan Javier) | - |
dc.creator | Rioja-Zuazu, J. (Jorge) | - |
dc.creator | Barba-Abad, J.F. (Javier Fermín) | - |
dc.creator | Tolosa-Eizaguirre, E. (Egoitz) | - |
dc.creator | Romero-Vargas, L. (Luis) | - |
dc.creator | Pascual-Piedrola, J.I. (Juan Ignacio) | - |
dc.date.accessioned | 2012-06-04T16:51:59Z | - |
dc.date.available | 2012-06-04T16:51:59Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Rincon Mayans A, Rosell Costa D, Zudaire Bergera JJ, Rioja Zuazu J, Barba Abad J, Tolosa Eizaguirre E, et al. Respuesta y supervivencia libre de progresión en tumores vesicales en estadiosT2-T4 tratados con tratamiento trimodal de conservación vesical. Actas Urol Esp 2010 Oct;34(9):775-780 | es_ES |
dc.identifier.issn | 0210-4806 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22448 | - |
dc.description.abstract | Objective: Toevaluatetheresponseandthefree-survivalprogressioninpacientsdiagnosed of invasivebladdercancerwhohavebeentreatedwithtransurethralresection, chemotherapyandradiotherapy.Thismultimodaltreatmentiscomparedwithanot random serieofpatientstreatedbyradicalcistectomy. Material andmethods: Retrospectiveanalysisof43casesofinvasivebladdercancertreated with twoschemesofbladderpreservationbetween1994–2007.Theyarecomparedwith145 cases treatedwithradicalcistectomyinthesameperiodoftime. Pronosticvariablesincludedinthestudyareclinicalstage,gradeofdifferentiation, presence ofureteralobstruction,chemotherapymodality,radiotherapydosesandp53and ki-67 expression. Results: Meanandmediantimeare51and39monthsinpatientswithmultimodal treatment.Completeresponseisachievedin72%ofcasestreatedwithbladder preservation.Ureteralobstructionisaprognosticfactor(OR:7,3;p:0,02).72%patientswith complete responsemantainitattheendofthestudy.Noneofanalyzedvariablesare predictors ofmaintenanceoftheresponse. Survivalrateswithaintactbladderwere6977% and6177% atthreeandfiveyears. Radiotherapydosesgreaterthan60Gy(OR:6,1;po0,001) andtheabsenceofureteral obstruction (OR:7,5;po0,002) werepronosticvariables. Free-survivalinpatientswithcompleteresponsewas8077% and58710% atthreeand five years. At theendofthestudy,53,5%ofpatientshadaintactbladderandfree-disease. Inthesameperiodoftime,145radicalcistectomieswereperformedduetomuscleinvasive bladdercancer.Meanandmediantimeinthisgroupwere29and18monthsrespectively. Stadisticalanalysisrevealsaworseclinicalstageinthegroupofpatientstreatedwith multimodaltreatment(p:0.01). Free-survivalwas7275% and6377%at3and5yearsinthegroupofradical cistectomies.Therewasnotstadisticalsignificantdifferencesbetweencistectomiesand bladderpreservation. Conclusions: Patientstreatedwithbladderpreservationhaveafree-survivalsimilartothose tretedwithradicalcistectomy.Radiotherapy doses greaterthan60Gyandabsenceofureteral obstructionwerefree-survivalprognosticvariables. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Elsevier España | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Bladder cancer | es_ES |
dc.subject | Quimiotherapy | es_ES |
dc.subject | Radiotherapy | es_ES |
dc.title | Respuesta y supervivencia libre de progresión en tumores vesicales en estadiosT2-T4 tratados con tratamiento trimodal de conservación vesical | es_ES |
dc.title.alternative | Response and progression-free survivalinT2toT4 bladder tumors treated with trimodality therapy with bladder preservation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/j.acuro.2010.04.008 | es_ES |
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