Antifibrinolytics Surgery Hemorrhage and thrombosis
Paramo JA. Hemorragia, hemostasia y trombosis en cirugía. Cir Esp 2009 Jun;85 Suppl 1:2-6.
Surgery is a leading cause of major hemorrhage as well as of thrombosis unless patients
are administered appropriate antithrombotic prophylaxis after their thrombo-hemorrhagic
risk has been stratified. Therefore, thorough preoperative evaluation is essential to
minimize surgical complications. In cases of incoercible bleeding, drugs such as desmopressin,
synthetic antifibrinolytics or recombinant factor VII can be administered. To prevent
postoperative thrombosis, low molecular weight heparins or pentasaccharide have
been shown to significantly reduce the incidence of thromboembolism.