Pardo-Mindan FJ, Guillen FJ, Villas C, Vazquez JJ. A comparative ultrastructural study of chondrosarcoma, chordoid sarcoma, and chordoma. Cancer. 1981 Jun 1;47(11):2611-9.
A morphologic and electron microscopic study was made of two chordoid sarcomas.
These lesions were compared with two classical chondrosarcomas and two chordomas.
These chondrosarcoma cells showed many features common to chondrocytes, such as
abundant RER, well-developed Golgi complexes, and microvillous cytoplasmatic
membranes. The chordoid sarcomas bore a close morphologic resemblance to the
chordomas but the ultrastructural features revealed a close relationship to the
chondrosarcomas. The chordoid sarcoma and chondrosarcoma cells had scalloped
cytoplasmatic membranes, variable amounts of glycogen, round or oval nuclei and
microfibrils, collagen, and electron-dense granules in the ground substance. The
chordoma was characterized by the presence of stellate and physalipherous cells,
as well as many transitional cells, with varying nuclear morphology; dilated and
irregular RER in contact with mitochondria and morphologically varied vacuoles
are the main features in the cytoplasm. This study suggests that chordoid sarcoma
represents a variety of the chondrosarcoma rather than a form of chordoma. These
findings also support the suggestion of Weiss that chordoid sarcoma is an
extraskeletal myxoid chondrosarcoma