Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Rocha, E. (Eduardo) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Montes, R. (Ramón) | - |
dc.creator | Panizo, C. (Carlos) | - |
dc.date.accessioned | 2012-10-24T11:06:56Z | - |
dc.date.available | 2012-10-24T11:06:56Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Rocha E, Martinez-Gonzalez MA, Montes R, Panizo C. Do the low molecular weight heparins improve efficacy and safety of the treatment of deep venous thrombosis? A meta-analysis. Haematologica 2000 Sep;85(9):935-942. | es_ES |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | https://hdl.handle.net/10171/23480 | - |
dc.description.abstract | We compared the efficacy and safety of low molecular weight heparins (LMWH) and unfractionated heparin (UFH) in the treatement of deep venous thrombosis (DVT). A comparison between two daily subcutaneous injections of LMWH against a single injection was also performed. DESIGN AND METHODS: The study was performed by a meta-analysis. Clot improvement in venography, recurrency, total mortality and major hemorrhages were assessed in 4,472 patients with DVT from 21 studies treated with subcutaneous LMWH or UFH. RESULTS: An improvement in clot reduction (odds ratio 0.73, 95% confidence interval 0.59 to 0.90, p = 0.004), a decrease in total mortality (0. 68, 0.50 to 0.91, p = 0.012) and a lower incidence of hemorrhage (0. 65, 0.43 to 0.98, p = 0.047) were observed in LMWH treated patients. There were no differences in recurrences (0.78, 0.59 to 1.04, p = 0. 10). A single dose of LMWH was better than two in reducing major bleeding (c2 = 4.99, p = 0.025); however, the two dose regimen was more effective in clot reduction (c2 = 8.56, p = 0.004). INTERPRETATION AND CONCLUSIONS: LMWH is superior to UFH in terms of safety and efficacy. A single daily dose of LMWH dose is a suitable therapeutic regimen and could facilitate the outpatient treatment of venous thromboembolism. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Ferrata Storti Foundation | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Hemorrhage/chemically induced | es_ES |
dc.subject | Heparin/standards/therapeutic use/toxicity | es_ES |
dc.subject | Heparin, Low-Molecular-Weight/standards/therapeutic use/toxicity | es_ES |
dc.title | Do the low molecular weight heparins improve efficacy and safety of the treatment of deep venous thrombosis? A meta-analysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.haematologica.org/content/85/9/935.long | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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