Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue

Ribeiro, R. (Ricardo); Monteiro, C. (Cátia); Catalan, V. (Victoria); Hu, P. (Pingzhao); Cunha, V. (Virginia); Rodriguez, A. (Amaia); Gomez-Ambrosi, J. (Javier); Fraga, A. (Avelino); Principe, P. (Paulo); Lobato, C. (Carlos); Lobo, F. (Francisco); Morais, A. (Antonio); Silva, V. (Vitor); Sanches-Magalhães, J. (José); Oliveira, J. (Jorge); Pina, F. (Francisco); Lopes, C. (Carlos); Medeiros, R. (Rui); Frühbeck, G. (Gema)

Keywords:

Body mass index
Disease progression
Microarray analysis

Issue Date:

2012

Publisher:

BioMed Central

Project:

SFRH/BD/30021/2006 - SFRH/BD/30021/2006 - FARMACOGENÓMICA E EPIDEMIOLOGIA MOLECULAR DE ADIPOCITOCINAS COM POTENCIAL ONCOLÓGICO - POLIMORFISMOS NOS GENES LEP, LEPR, AMP1, VEGF, TNFA E SUSCEPTIBILIDADE PARA CANCRO E MODELO DE PROGNÓSTICO EM TUMORES SÓLIDOS
PTDC/SAU-ONC/112511/2009 - - Effect of radio- and chemotherapy on cancer cell invasion: the role of macrophages

ISSN:

1741-7015

Citation:

Ribeiro R, Monteiro C, Catalán V, Hu P, Cunha V, Rodríguez A. Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Med. 2012 Sep 25;10:108.

Abstract

Obesity and excess adiposity modified the expression of PP adipose tissue genes to ultimately foster fat mass growth. In patients with prostate cancer the expression profile of PP adipose tissue accounted for hypercellularity and reduced immunosurveillance. Both findings may be liable to promote a favorable environment for prostate cancer progression.

URI:

https://hdl.handle.net/10171/35346

Appears in Collections:

DA - CUN - Endocrinología y Nutrición - Artículos de revista

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