Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Redgrave, P. (Peter) | - |
dc.creator | Rodriguez-Diaz, M. (Manuel) | - |
dc.creator | Smith, Y. (Yoland) | - |
dc.creator | Rodriguez-Oroz, M.C. (María Cruz) | - |
dc.creator | Lehericy, S. (Stephane) | - |
dc.creator | Bergman, H. (Hagai) | - |
dc.creator | Agid, Y. (Yves) | - |
dc.creator | DeLong, M.R. (Mahlon R.) | - |
dc.creator | Obeso, J.A. (José A.) | - |
dc.date.accessioned | 2014-08-12T11:00:40Z | - |
dc.date.available | 2014-08-12T11:00:40Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | Redgrave P, Rodriguez M, Smith Y, Rodriguez-Oroz MC, Lehericy S, Bergman H, et al. Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease. Nat Rev Neurosci. 2010 Nov;11(11):760-72. | es_ES |
dc.identifier.issn | 1471-003X | - |
dc.identifier.uri | https://hdl.handle.net/10171/36302 | - |
dc.description.abstract | Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Parkinson Disease/physiopathology | es_ES |
dc.subject | Models, Neurological | es_ES |
dc.subject | Nerve Net/pathology | es_ES |
dc.subject | Neural Pathways/pathology | es_ES |
dc.title | Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1038/nrn2915 | es_ES |
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