Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Perez-Simon, J.A. (José Antonio) | - |
dc.creator | Lopez-Villar, O. (Olga) | - |
dc.creator | Andreu, E.J. (Enrique José) | - |
dc.creator | Rifon, J. J. (Jose J.) | - |
dc.creator | Muntion, S. (Sandra) | - |
dc.creator | Diez-Campelo, M. (M.) | - |
dc.creator | Sanchez-Guijo, F.M. (Fermín M.) | - |
dc.creator | Martinez, C. (Carmen) | - |
dc.creator | Valcarcel, D. (David) | - |
dc.creator | Cañizo, C. (C.) del | - |
dc.date.accessioned | 2014-08-30T17:50:02Z | - |
dc.date.available | 2014-08-30T17:50:02Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | Pérez-Simón JA, López-Villar O, Andreu EJ, Rifón J, Muntion S, Campelo MD, et al. Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial. Haematologica. 2011 Jul;96(7):1072-1076 | es_ES |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | https://hdl.handle.net/10171/36422 | - |
dc.description.abstract | This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for the treatment of refractory acute or chronic graft-versus-host disease. Twenty-eight expansions were started. In 22, a minimum of more than 1 x 10⁶ mesenchymal stem cells/kg were obtained after a median of 26 days; this threshold was not obtained in the remaining cases. Ten patients received cells for the treatment of refractory or relapsed acute graft-versus-host disease and 8 for chronic disease. One patient treated for acute graft-versus-host disease obtained a complete response, 6 had a partial response and 3 did not respond. One of the chronic patients achieved complete remision, 3 a partial response, and 4 did not respond. The current study supports the use of this approach in less heavily treated patients for both acute and chronic graft-versus-host disease. The trial has been registered at ClinicalTrials.gov: identifier NCT00447460. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Ferrata Storti Foundation | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Graft versuss Host disease | es_ES |
dc.subject | Treatment outcome | es_ES |
dc.subject | Cells | es_ES |
dc.subject | Mesenchymal stromal cells | es_ES |
dc.subject | Clinical trial, Phase I | es_ES |
dc.subject | Clinical trial, Phase II | es_ES |
dc.subject | Humans | es_ES |
dc.subject | Transplantation, homologous | es_ES |
dc.title | Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.3324/haematol.2010.038356 | es_ES |
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