Full metadata record
DC Field | Value | Language |
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dc.creator | Garbayo, E | - |
dc.creator | Gavira, J.J. (Juan José) | - |
dc.creator | Garcia-de-Yebenes, M. (Manuel) | - |
dc.creator | Pelacho, B. (Beatriz) | - |
dc.creator | Abizanda-Sarasa, G. (Gloria) | - |
dc.creator | Lana, H. (Hugo) | - |
dc.creator | Blanco-Prieto, M.J. (María José) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.date.accessioned | 2016-06-13T08:32:24Z | - |
dc.date.available | 2016-06-13T08:32:24Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Garbayo E, Gavira JJ, Garcia-de-Yebenes M, Pelacho B, Abizanda G, Lana H, et al. Catheter-based intramyocardial injection of FGF1 or NRG1-loaded MPs improves cardiac function in a preclinical model of ischemia-reperfusion. Sci Rep. 2016;6:1-12 | es_ES |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10171/41316 | - |
dc.description.abstract | Cardiovascular protein therapeutics such as neuregulin (NRG1) and acidic-fibroblast growth factor (FGF1) requires new formulation strategies that allow for sustained bioavailability of the drug in the infarcted myocardium. However, there is no FDA-approved injectable protein delivery platform due to translational concerns about biomaterial administration through cardiac catheters. We therefore sought to evaluate the efficacy of percutaneous intramyocardial injection of poly(lactic-co-glycolic acid) microparticles (MPs) loaded with NRG1 and FGF1 using the NOGA MYOSTAR injection catheter in a porcine model of ischemia-reperfusion. NRG1- and FGF1-loaded MPs were prepared using a multiple emulsion solvent-evaporation technique. Infarcted pigs were treated one week after ischemiareperfusion with MPs containing NRG1, FGF1 or non-loaded MPs delivered via clinically-translatable percutaneous transendocardial-injection. Three months post-treatment, echocardiography indicated a significant improvement in systolic and diastolic cardiac function. Moreover, improvement in bipolar voltage and decrease in transmural infarct progression was demonstrated by electromechanical NOGA-mapping. Functional benefit was associated with an increase in myocardial vascularization and remodeling. These findings in a large animal model of ischemia-reperfusion demonstrate the feasibility and efficacy of using MPs as a delivery system for growth factors and provide strong evidence to move forward with clinical studies using therapeutic proteins combined with catheter-compatible biomaterials. | es_ES |
dc.description.sponsorship | Spanish Ministry of Sciences and Innovations (JCI-2011-10737), Spanish Ministry of Economy and Competitiveness (SAF2013‐42528‐R), the Instituto de Salud Carlos III (ISCIII) PI10/01621, PI13/02144, CP09/00333 and ISCIII-RETIC RD12/0019/0031, PLE2009- 0116 and INNPACTO Procardio, the EU FPVII program (INELPY), and the “UTE project CIMA”. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Catheter-based intramyocardial Injection | es_ES |
dc.subject | Cardiac function | es_ES |
dc.subject | Ischemia- reperfusion | es_ES |
dc.subject | Neuregulin (NRG1) | es_ES |
dc.subject | Acidic-fibroblast growth factor (FGF1) | es_ES |
dc.subject | Materias Investigacion::Farmacia::Tecnología farmacéutica | es_ES |
dc.title | Catheter-based intramyocardial injection of FGF1 or NRG1-loaded MPs improves cardiac function in a preclinical model of ischemia-reperfusion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1038/srep25932. | es_ES |
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